| Title: |
Neurodevelopmental Outcomes of Children Following In Utero Exposure to Zika in Nicaragua |
| Authors: |
Stringer, Elizabeth M; Martinez, Evelin; Blette, Bryan; Toval Ruiz, Christian Eduardo; Boivin, Michael; Zepeda, Omar; Stringer, Jeffrey S A; Morales, Marlen; Ortiz-Pujols, Shiara; Familiar, Itziar; Collins, Matthew; Chavarria, Meylin; Goldman, Barbara; Bowman, Natalie; de Silva, Aravinda; Westreich, Daniel; Hudgens, Michael; Becker-Dreps, Sylvia; Bucardo, Filemon |
| Contributors: |
Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases |
| Source: |
Clinical Infectious Diseases ; volume 72, issue 5, page e146-e153 ; ISSN 1058-4838 1537-6591 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2021 |
| Description: |
Background Neurodevelopmental outcomes of asymptomatic children exposed to Zika virus (ZIKV) in utero are not well characterized. Methods We prospectively followed 129 newborns without evidence of congenital Zika syndrome (CZS) up to 24 months of age. Participants were classified as ZIKV exposed or ZIKV unexposed. The Mullen Scales of Early Learning (MSEL) was administered in the participants’ homes at 6, 12, 15, 18, 21, and 24 months of age by trained psychologists. Sociodemographic data, medical history, and infant anthropometry at birth were collected at each home visit. Our primary outcome was the Mullen Early Learning Composite Score (ECL) at 24 months of age between our 2 exposure groups. Secondary outcomes were differences in MSEL subscales over time and at 24 months. Results Of 129 infants in whom exposure status could be ascertained, 32 (24.8%) met criteria for in utero ZIKV exposure and 97 (75.2%) did not. There were no differences in maternal age, maternal educational attainment, birthweight, or gestational age at birth between the 2 exposure groups. The adjusted means and standard errors (SEs) for the ELC score between the ZIKV-exposed children compared to ZIKV-unexposed children were 91.4 (SE, 3.1) vs 96.8 (SE, 2.4) at 12 months and 93.3 (SE, 2.9) vs 95.9 (SE, 2.3) at 24 months. In a longitudinal mixed model, infants born to mothers with an incident ZIKV infection (P = .01) and low-birthweight infants ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/cid/ciaa1833 |
| DOI: |
10.1093/cid/ciaa1833/36156028/ciaa1833.pdf |
| Availability: |
https://doi.org/10.1093/cid/ciaa1833; http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa1833/36156028/ciaa1833.pdf; http://academic.oup.com/cid/article-pdf/72/5/e146/36415796/ciaa1833.pdf |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.C902E133 |
| Database: |
BASE |