Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder
| Title: | Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder |
|---|---|
| Authors: | de Zwarte, Sonja M.C.; Brouwer, Rachel M.; Agartz, Ingrid; Alda, Martin; Alonso-Lana, Silvia; Bearden, Carrie E.; Bertolino, Alessandro; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabeth E.L.; Cahn, Wiepke; Canales-Rodríguez, Erick J.; Cannon, Dara M.; Cannon, Tyrone D.; Caseras, Xavier; Castro-Fornieles, Josefina; Chen, Qiang; Chung, Yoonho; De la Serna, Elena; del Mar Bonnin, Caterina; Demro, Caroline; Di Giorgio, Annabella; Doucet, Gaelle E.; Eker, Mehmet Cagdas; Erk, Susanne; Fatjó-Vilas, Mar; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Fullerton, Janice M.; Glahn, David C.; Goghari, Vina M.; Goikolea, Jose M.; Goldman, Aaron L.; Gonul, Ali Saffet; Gruber, Oliver; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hidiroglu Ongun, Ceren; Hillegers, Manon H.J.; Houenou, Josselin; Hulshoff Pol, Hilleke E.; Hultman, Christina M.; Ingvar, Martin; Johansson, Viktoria; Jönsson, Erik G.; Kane, Fergus; Kempton, Matthew J.; Koenis, Marinka M.G.; Kopecek, Miloslav; Krämer, Bernd; Lawrie, Stephen M.; Lenroot, Rhoshel K.; Marcelis, Machteld; Mattay, Venkata S.; McDonald, Colm; Meyer-Lindenberg, Andreas; Michielse, Stijn; Mitchell, Philip B.; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Nabulsi, Leila; Newport, Jason; Olman, Cheryl A.; van Os, Jim; Overs, Bronwyn J.; Ozerdem, Aysegul; Pergola, Giulio; Picchioni, Marco M.; Piguet, Camille; Pomarol-Clotet, Edith; Radua, Joaquim; Ramsay, Ian S.; Richter, Anja; Roberts, Gloria; Salvador, Raymond; Saricicek Aydogan, Aybala; Sarró, Salvador; Schofield, Peter R.; Simsek, Esma M.; Simsek, Fatma; Soares, Jair C.; Sponheim, Scott R.; Sugranyes, Gisela; Toulopoulou, Timothea; Tronchin, Giulia; Vieta, Eduard; Walter, Henrik; Weinberger, Daniel R.; Whalley, Heather C.; Wu, Mon Ju; Yalin, Nefize; Andreassen, Ole A.; Ching, Christopher R.K.; Thomopoulos, Sophia I.; van Erp, Theo G.M.; Jahanshad, Neda; Thompson, Paul M.; Kahn, René S.; van Haren, Neeltje E.M. |
| Source: | de Zwarte, S M C, Brouwer, R M, Agartz, I, Alda, M, Alonso-Lana, S, Bearden, C E, Bertolino, A, Bonvino, A, Bramon, E, Buimer, E E L, Cahn, W, Canales-Rodríguez, E J, Cannon, D M, Cannon, T D, Caseras, X, Castro-Fornieles, J, Chen, Q, Chung, Y, De la Serna, E, del Mar Bonnin, C, Demro, C, Di Giorgio, A, Doucet, G E, Eker, M C, Erk, S, Fatjó-Vilas, M, Fears, S C, Foley, S F, Frangou, S, Fullerton, J M, Glahn, D C, Goghari, V M, Goikolea, J M, Goldman, A L, Gonul, A S, Gruber, O, Hajek, T, .... |
| Publication Year: | 2022 |
| Description: | First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = −0.42, p = 3 × 10 −5 ), with weak evidence of IQ reductions among BD-FDRs (d = −0.23, p =.045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1065-9471; 1097-0193 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33027543; info:eu-repo/semantics/altIdentifier/wos/000575642800001; info:eu-repo/semantics/altIdentifier/pissn/1065-9471; info:eu-repo/semantics/altIdentifier/eissn/1097-0193 |
| DOI: | 10.1002/hbm.25206 |
| Availability: | https://pure.eur.nl/en/publications/817c8c8b-420e-4917-9ec3-e9a249649b77; https://doi.org/10.1002/hbm.25206; https://pure.eur.nl/ws/files/45631387/Intelligence_educational_attainment_and_brain_structure_in_those_at_familial_high_risk_for_schizophrenia_or_bipolar_disorder.pdf; https://www.scopus.com/pages/publications/85092137687; https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:000575642800001&DestLinkType=FullRecord&DestApp=WOS |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.C916C572 |
| Database: | BASE |