Therapeutic Duplicates in a Cohort of Hospitalized Elderly Patients: Results from the REPOSI Study
| Title: | Therapeutic Duplicates in a Cohort of Hospitalized Elderly Patients: Results from the REPOSI Study |
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| Authors: | Pasina L; Astuto S; Cortesi L; Tettamanti M; Franchi C; Marengoni A; Mannucci PM; Nobili A; REPOSI Investigators: Prisco D; Silvestri E; Cenci C; Emmi G; Biolo G; Zanetti M; Guadagni M; Zaccari M; Vanoli M; Grignani G; Pulixi EA; Bernardi M; Bassi SL; Santi L; Zaccherini G; Mannarino E; Lupattelli G; Bianconi V; Paciullo F; Nuti R; Valenti R; Ruvio M; Cappelli S; Palazzuoli A; Olivieri O; Girelli D; Matteazzi T; Barbagallo M; Dominguez L; Cocita F; Beneduce V; Plances L; Zoli M; Lazzari I; Brunori M; Pasini FL; Capecchi PL; Palasciano G; Modeo ME; Di Gennaro C; Cappellini MD; Maira D; Di Stefano V; Fabio G; Seghezzi S; Mancarella M; Cesari M; Rossi PD; Damanti S; Clerici M; Conti F; Corazza GR; Miceli E; Lenti MV; Pisati M; Dominioni CC; Murialdo G; Marra A; Cattaneo F; Secchi MB; Ghelfi D; Anastasio L; Sofia L; Carbone M; Cipollone F; Guagnano MT; Angelucci E; Valeriani E; Mancuso G; Calipari D; Bartone M; Delitala G; Berria M; Muscaritoli M; Molfino A; Petrillo E; Zuccalà G; D'Aurizio G; Romanelli G; Zucchelli A; Picardi A; Gentilucci UV; Gallo P; Dell'Unto C; Annoni G; Corsi M; Bellelli G; Zazzetta S; Mazzola P; Szabo H; Bonfanti A; Arturi F; Succurro E; Rubino M; Serra MG; Bleve MA; Gasbarrone L; Sajeva MR; Brucato A; Ghidoni S; Fabris F; Bertozzi I; Bogoni G; Rabuini MV; Cosi E; Manfredini R; Fabbian F; Boari B; De Giorgi A; Tiseo R; Paolisso G; Rizzo MR; Borghi C; Strocchi E; De Sando V; Pareo I; Sabbà C; Vella FS; Suppressa P; Agosti P; Schilardi A; Loparco F; Fenoglio L; Bracco C; Giraudo AV; Fargion S; Periti G; Porzio M; Tiraboschi S; Peyvandi F; Rossio R; Ferrari B; Colombo G; Monzani V; Savojardo V; Folli C; Ceriani G; Salerno F; Pallini G; Dallegri F; Ottonello L; Liberale L; Caserza L; Salam K; Liberato NL; Tognin T; Bianchi GB; Giaquinto S; Purrello F; Di Pino A; Piro S; Rozzini R; Falanga L; Spazzini E; Ferrandina C; Montrucchio G; Petitti P; Salmi R; Gaudenzi P; Violi F; Perri L; Landolfi R; Montalto M; Mirijello A; Guasti L; Castiglioni L; Maresca A; Squizzato A; Molaro M; Grossi A; Bertolotti M; Mussi C; Libbra MV; Dondi G; Pellegrini E; Carulli L; Perticone F; Colangelo L; Falbo T; Stanghellini V; De Giorgio R; Ruggeri E; Del Vecchio S; Salvi A; Leonardi R; Damiani G; Gabrielli A; Capeci W; Mattioli M; Martino GP; Biondi L; Pettinari P; Ghio R; Col AD; Minisola S; Afeltra A; Marigliano B; Pipita ME; Castellino P; Blanco J; Zanoli L; Pignataro S; Saracco V; Fogliati M; Bussolino C; Mete F; Gino M; Cittadini A; Vigorito C; Arcopinto M; Salzano A; Bobbio E; Marra AM; Sirico D; Moreo G; Gasparini F; Prolo S; Pina G; Ballestrero A; Ferrando F; Berra S; Dassi S; Nava MC; Graziella B; Baldassarre S; Fragapani S; Gruden G; Galanti G; Mascherini G; Petri C; Stefani L; Girino M; Piccinelli V; Nasso F; Gioffrè V; Pasquale M; Scattolin G; Martinelli S; Turrin M; Sechi L; Catena C; Colussi G; Passariello N; Rinaldi L; Berti F; Famularo G; Patrizia T; Castello R; Pasino M; Ceda GP; Maggio MG; Morganti S; Artoni A; Del Giacco S; Firinu D; Losa F; Paoletti G; Montalto G; Licata A; Malerba V; Antonino L; Basile G; Antonino C; Malatino L; Stancanelli B; Terranova V; Di Marca S; Mecocci P; Ruggiero C; Boccardi V; Meschi T; Lauretani F; Ticinesi A; Minuz P; Fondrieschi L; Pirisi M; Fra GP; Sola D; Porta M; Riva P; Quadri R; Scanzi G; Mengoli C; Provini S; Ricevuti L; Simeone E; Scurti R; Tolloso F; Tarquini R; Valoriani A; Dolenti S; Vannini G; Tedeschi A; Trotta L; Volpi R; Bocchi P; Vignali A; Harari S; Lonati C; Cattaneo M; Nieves RD; Alberto MM; Pedro AR; Vanessa LP; Lara T; Xavier CV; Francesc F; Jesus DM; Esperanza BT; Esther DCB; Maria SP; Romero M; Blanca PL; Cristina LG; Victoria VGM; Saez L; Bosco J; Susana SB; Marta AG; Concepcion GB; Antonio FM; Hernandez MG; Borrego MP; Raquel PC; Florencia PR; Beatriz GO; Sara CG; Alfonso GC; Marta PM; Garcia SC; Alberto RC; Antonio AA; Montserrat GG; Ángel BRM; Manuel MJ; Ignacio NV; Lucía AS; Alfonso L; David RB; Iria IV; Monica RP |
| Contributors: | Pasina, L; Astuto, S; Cortesi, L; Tettamanti, M; Franchi, C; Marengoni, A; Mannucci, Pm; Nobili, A; REPOSI Investigators: Prisco, D; Silvestri, E; Cenci, C; Emmi, G; Biolo, G; Zanetti, M; Guadagni, M; Zaccari, M; Vanoli, M; Grignani, G; Pulixi, Ea; Bernardi, M; Bassi, Sl; Santi, L; Zaccherini, G; Mannarino, E; Lupattelli, G; Bianconi, V; Paciullo, F; Nuti, R; Valenti, R; Ruvio, M; Cappelli, S; Palazzuoli, A; Olivieri, O; Girelli, D; Matteazzi, T; Barbagallo, M; Dominguez, L; Cocita, F; Beneduce, V; Plances, L; Zoli, M; Lazzari, I; Brunori, M; Pasini, Fl; Capecchi, Pl; Palasciano, G; Modeo, Me; Di Gennaro, C; Cappellini, Md; Maira, D; Di Stefano, V; Fabio, G; Seghezzi, S; Mancarella, M; Cesari, M; Rossi, Pd; Damanti, S; Clerici, M; Conti, F; Corazza, Gr; Miceli, E; Lenti, Mv; Pisati, M; Dominioni, Cc; Murialdo, G; Marra, A; Cattaneo, F; Secchi, Mb; Ghelfi, D; Anastasio, L; Sofia, L; Carbone, M; Cipollone, F; Guagnano, Mt; Angelucci, E; Valeriani, E; Mancuso, G; Calipari, D; Bartone, M; Delitala, G; Berria, M; Muscaritoli, M; Molfino, A; Petrillo, E; Zuccalà, G; D'Aurizio, G; Romanelli, G; Zucchelli, A; Picardi, A; Gentilucci, Uv; Gallo, P; Dell'Unto, C; Annoni, G; Corsi, M; Bellelli, G; Zazzetta, S; Mazzola, P; Szabo, H; Bonfanti, A |
| Publication Year: | 2016 |
| Collection: | IRIS Università degli Studi di Perugia |
| Subject Terms: | Aged; 80 and over; Cross-Sectional Studie; Drug Interaction; Drug Prescription; Drug-Related Side Effects and Adverse Reaction; Female; Hospital Department; Hospitalization; Human; Inappropriate Prescribing; Italy; Male; Prevalence; Prospective Studie; Risk; Patient Discharge; Polypharmacy |
| Description: | Background: Explicit criteria for potentially inappropriate prescriptions in the elderly are recommended to avoid prescriptions of duplicate drug classes and to optimize monotherapy within a single drug class before a new agent is considered. Duplicate drug class prescription (or therapeutic duplicates) puts the patient at increased risk of adverse drug reactions with no additional therapeutic benefits. To our knowledge, the prevalence of elderly inpatients receiving therapeutic duplicates has never been studied. Objectives: Our objective was to assess the prevalence of therapeutic duplicates at admission, discharge, and 3-month follow-up of hospitalized elderly patients. Methods: This cross-sectional prospective study was conducted in 97 Italian internal medicine and geriatric wards. Therapeutic duplicates were defined as at least two drugs of the same therapeutic class prescribed simultaneously to a patient. A patient’s drug therapy at admission relates to prescriptions from general practitioners, whereas prescriptions at discharge are those from hospital internists or geriatricians. Results: The study sample comprised 5821 admitted and 4983 discharged patients. In all, 143 therapeutic duplicates were found at admission and 170 at discharge. The prevalence of patients exposed to at least one therapeutic duplicate rose significantly from hospital admission (2.5 %) to discharge (3.4 %; p = 0.0032). Psychotropic drugs and drugs for peptic ulcer or gastroesophageal reflux disease were the most frequently involved. A total of 86.8 % of patients discharged with at least one therapeutic duplicate were still receiving them at 3-month follow-up. Conclusions: Hospitalization and drugs prescribed by internists and geriatricians are both factors associated with a small but definite increase in overall therapeutic duplicates in elderly patients admitted to internal medicine and geriatric wards. More attention should be paid to the indications for each drug prescribed, because therapeutic duplicates are not supported by ... |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/27581548; info:eu-repo/semantics/altIdentifier/wos/WOS:000384433400004; volume:33; issue:9; firstpage:647; lastpage:654; numberofpages:8; journal:DRUGS & AGING; https://hdl.handle.net/11391/1459520; http://rd.springer.com/journal/40266 |
| DOI: | 10.1007/s40266-016-0395-9 |
| Availability: | https://hdl.handle.net/11391/1459520; https://doi.org/10.1007/s40266-016-0395-9; http://rd.springer.com/journal/40266 |
| Accession Number: | edsbas.C93E6014 |
| Database: | BASE |