| Title: |
Ictal Bradycardia and Asystole in Sleep-Related Hypermotor Epilepsy: A Study of 200 Patients |
| Authors: |
Muccioli L.; Bruschi G.; Ferri L.; Scarabello A.; Taruffi L.; Di Vito L.; Mostacci B.; Provini F.; Calandra Buonaura G.; Tinuper P.; Licchetta L.; Bisulli F. |
| Contributors: |
Muccioli, L.; Bruschi, G.; Ferri, L.; Scarabello, A.; Taruffi, L.; Di Vito, L.; Mostacci, B.; Provini, F.; Calandra Buonaura, G.; Tinuper, P.; Licchetta, L.; Bisulli, F. |
| Publication Year: |
2024 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
arrhythmia; DEPDC5; focal cortical dysplasia (FCD); GATOR1; genetic; heart; MRI; polygraphy; seizure; SUDEP |
| Description: |
Background: Ictal bradycardia (IB) and asystole (IA) represent a rare but potentially harmful feature of epileptic seizures. The aim of this study was to study IB/IA in patients with sleep-related hypermotor epilepsy (SHE). Methods: We retrospectively included cases with video-EEG-confirmed SHE who attended our Institute up to January 2021. We reviewed the ictal polysomnography recordings focusing on ECG and identified cases with IB (R-R interval ≥ 2 s or a ≥10% decrease of baseline heart rate) and IA (R-R interval ≥ 4 s). Results: We included 200 patients (123 males, 61.5%), with a mean age of 42 ± 16 years. Twenty patients (20%) had focal cortical dysplasia (FCD) on brain MRI. Eighteen (out of 104 tested, 17.3%) carried pathogenic variants (mTOR pathway, n = 10, nAchR subunits, n = 4, KCNT1, n = 4). We identified IB/IA in four cases (2%): three had IA (mean 10 s) and one had IB. Three patients had FCD (left fronto-insular region, left amygdala, right mid-temporal gyrus) and two had pathogenic variants in DEPDC5; both features were more prevalent in patients with IB/IA than those without (p = 0.003 and p = 0.037, respectively). Conclusions: We identified IB/IA in 2% of patients with SHE and showed that this subgroup more frequently had FCD on brain MRI and pathogenic variants in genes related to the mTOR pathway. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38541990; info:eu-repo/semantics/altIdentifier/wos/WOS:001192977500001; volume:13; issue:6; firstpage:1; lastpage:12; numberofpages:12; journal:JOURNAL OF CLINICAL MEDICINE; https://hdl.handle.net/11585/1010254 |
| DOI: |
10.3390/jcm13061767 |
| Availability: |
https://hdl.handle.net/11585/1010254; https://doi.org/10.3390/jcm13061767; https://www.mdpi.com/2077-0383/13/6/1767 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C98FF178 |
| Database: |
BASE |