| Title: |
The European MAPPYACTS Trial: Precision Medicine Program in Pediatric and Adolescent Patients with Recurrent Malignancies |
| Authors: |
Berlanga, Pablo; Pierron, Gaelle; Lacroix, Ludovic; Chicard, Mathieu; Adam de Beaumais, Tiphaine; Marchais, Antonin; Soriano Fernández, Aroa; Hladun Alvaro, Raquel |
| Contributors: |
Institut Català de la Salut; Berlanga P Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Pierron G Unité de Génétique Somatique, Service de Génétique, Hospital Group, Institut Curie, Paris, France. Lacroix L Department of Pathology and Laboratory Medicine, Translational Research Laboratory and Biobank, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Chicard M INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, PSL Research University, Institut Curie, Paris, France. Adam de Beaumais T Clinical Research Direction, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Marchais A INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Soriano Fernandez A Grup de Recerca Translacional en Càncer en la Infància i l’Adolescència, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Hladun-Alvaro R Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Oncologia i Hematologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain; Vall d'Hebron Barcelona Hospital Campus |
| Source: |
Scientia |
| Publisher Information: |
American Association for Cancer Research |
| Publication Year: |
2022 |
| Subject Terms: |
Càncer - Recaiguda; Medicina personalitzada; Pediatria; DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Recurrence; Local; ANALYTICAL; DIAGNOSTIC AND THERAPEUTIC TECHNIQUES; AND EQUIPMENT::Therapeutics::Precision Medicine; DISEASES::Neoplasms; ENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica local; TÉCNICAS Y EQUIPOS ANALÍTICOS; DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::medicina de precisión; ENFERMEDADES::neoplasias |
| Description: |
Precision Medicine; Pediatric and Adolescent Patients; Recurrent Malignancies ; Medicina de Precisión; Pacientes pediátricos y adolescentes; Neoplasias malignas recurrentes ; Medicina de precisió; Pacients pediàtrics i adolescents; Neoplasmes malignes recurrents ; MAPPYACTS (NCT02613962) is an international prospective precision medicine trial aiming to define tumor molecular profiles in pediatric patients with recurrent/ refractory malignancies in order to suggest the most adapted salvage treatment. From February 2016 to July 2020, 787 patients were included in France, Italy, Ireland, and Spain. At least one genetic alteration leading to a targeted treatment suggestion was identified in 436 patients (69%) with successful sequencing; 10% of these alterations were considered “ready for routine use.” Of 356 patients with follow-up beyond 12 months, 107 (30%) received one or more matched targeted therapies—56% of them within early clinical trials—mainly in the AcSé-ESMART platform trial (NCT02813135). Overall, matched treatment resulted in a 17% objective response rate, and of those patients with ready for routine use alterations, it was 38%. In patients with extracerebral tumors, 76% of actionable alterations detected in tumor tissue were also identified in circulating cell-free DNA (cfDNA). |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Cancer Discovery;12(5); https://doi.org/10.1158/2159-8290.CD-21-1136; Berlanga P, Pierron G, Lacroix L, Chicard M, Adam de Beaumais T, Marchais A, et al. The European MAPPYACTS Trial: Precision Medicine Program in Pediatric and Adolescent Patients with Recurrent Malignancies. Cancer Discov. 2022 May 1;12(5):1266–81.; https://hdl.handle.net/11351/8044; 000795663800001 |
| DOI: |
10.1158/2159-8290.CD-21-1136 |
| Availability: |
https://hdl.handle.net/11351/8044; https://doi.org/10.1158/2159-8290.CD-21-1136 |
| Rights: |
Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C9B9929E |
| Database: |
BASE |