| Title: |
Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: an international multi-centre observational cohort study |
| Authors: |
Tan, Byorn W. L.; Tan, Bryce W. Q.; Tan, Amelia L. M.; Schriver, Emily R.; Gutiérrez-Sacristán, Alba; Das, Priyam; Yuan, William; Hutch, Meghan R.; García Barrio, Noelia; Pedrera Jimenez, Miguel; Abu-el-rub, Noor; Morris, Michele; Moal, Bertrand; Verdy, Guillaume; Cho, Kelly; Ho, Yuk-Lam; Patel, Lav P.; Dagliati, Arianna; Neuraz, Antoine; Klann, Jeffrey G.; South, Andrew M.; Visweswaran, Shyam; Hanauer, David A.; Maidlow, Sarah E.; Liu, Mei; Mowery, Danielle L.; Batugo, Ashley; Makoudjou, Adeline; Tippmann, Patric; Zöller, Daniela; Brat, Gabriel A.; Luo, Yuan; Avillach, Paul; Bellazzi, Riccardo; Chiovato, Luca; Malovini, Alberto; Tibollo, Valentina; Samayamuthu, Malarkodi Jebathilagam; Serrano Balazote, Pablo; Xia, Zongqi; Loh, Ne Hooi Will; Chiudinelli, Lorenzo; Bonzel, Clara-Lea; Hong, Chuan; Zhang, Harrison G.; Weber, Griffin M.; Kohane, Isaac S.; Cai, Tianxi; Omenn, Gilbert S.; Holmes, John H.; Ngiam, Kee Yuan; Aaron, James R.; Agapito, Giuseppe; Albayrak, Adem; Albi, Giuseppe; Alessiani, Mario; Alloni, Anna; Amendola, Danilo F.; Angoulvant, François; Anthony, Li L. L. J.; Aronow, Bruce J.; Ashraf, Fatima; Atz, Andrew; Panickan, Vidul Ayakulangara; Azevedo, Paula S.; Balshi, James; Beaulieu-Jones, Brett K.; Beaulieu-Jones, Brendin R.; Bell, Douglas S.; Bellasi, Antonio; Benoit, Vincent; Beraghi, Michele; Bernal-Sobrino, José Luis; Bernaux, Mélodie; Bey, Romain; Bhatnagar, Surbhi; Blanco-Martínez, Alvar; Boeker, Martin; Booth, John; Bosari, Silvano; Bourgeois, Florence T.; Bradford, Robert L.; Bréant, Stéphane; Brown, Nicholas W.; Bruno, Raffaele; Bryant, William A.; Bucalo, Mauro; Bucholz, Emily; Burgun, Anita; Cannataro, Mario; Carmona, Aldo; Cattelan, Anna Maria; Caucheteux, Charlotte; Champ, Julien; Chen, Jin; Chen, Krista Y.; Cimino, James J.; Colicchio, Tiago K.; Cormont, Sylvie; Cossin, Sébastien; Craig, Jean B.; Cruz-Bermúdez, Juan Luis; Cruz-Rojo, Jaime; Daniar, Mohamad; Daniel, Christel; Devkota, Batsal; Dionne, Audrey; Duan, Rui; Dubiel, Julien; DuVall, Scott L.; Esteve, Loic; Estiri, Hossein; Fan, Shirley; Follett, Robert W.; Ganslandt, Thomas; García-Barrio, Noelia; Garmire, Lana X.; Gehlenborg, Nils; Getzen, Emily J.; Geva, Alon; González, Tomás González; Gradinger, Tobias; Gramfort, Alexandre; Griffier, Romain; Griffon, Nicolas; Grisel, Olivier; Guzzi, Pietro H.; Han, Larry; Haverkamp, Christian; Hazard, Derek Y.; He, Bing; Henderson, Darren W.; Hilka, Martin; Honerlaw, Jacqueline P.; Huling, Kenneth M.; Issitt, Richard W.; Jannot, Anne Sophie; Jouhet, Vianney; Kavuluru, Ramakanth; Keller, Mark S.; Kennedy, Chris J.; Kernan, Kate F.; Key, Daniel A.; Kirchoff, Katie; Krantz, Ian D.; Kraska, Detlef; Krishnamurthy, Ashok K.; L'Yi, Sehi; Le, Trang T.; Leblanc, Judith; Lemaitre, Guillaume; Lenert, Leslie; Leprovost, Damien; Liu, Molei; Will Loh, Ne Hooi; Long, Qi; Lozano-Zahonero, Sara; Lynch, Kristine E.; Mahmood, Sadiqa; Makwana, Simran; Mandl, Kenneth D.; Mao, Chengsheng; Maram, Anupama; Maripuri, Monika; Martel, Patricia; Martins, Marcelo R.; Marwaha, Jayson S.; Masino, Aaron J.; Mazzitelli, Maria; Mazzotti, Diego R.; Mensch, Arthur; Milano, Marianna; Minicucci, Marcos F.; Ahooyi, Taha Mohseni; Moore, Jason H.; Moraleda, Cinta; Morris, Jeffrey S.; Moshal, Karyn L.; Mousavi, Sajad; Murad, Douglas A.; Murphy, Shawn N.; Naughton, Thomas P.; Breda Neto, Carlos Tadeu; Newburger, Jane; Njoroge, Wanjiku F. M.; Norman, James B.; Obeid, Jihad; Okoshi, Marina P.; Olson, Karen L.; Orlova, Nina; Ostasiewski, Brian D.; Palmer, Nathan P.; Paris, Nicolas; Pedrera-Jiménez, Miguel; Pfaff, Ashley C.; Pfaff, Emily R.; Pillion, Danielle; Pizzimenti, Sara; Priya, Tanu; Prokosch, Hans U.; Prudente, Robson A.; Prunotto, Andrea; Quirós-González, Víctor; Ramoni, Rachel B.; Raskin, Maryna; Rieg, Siegbert; Roig-Domínguez, Gustavo; Rojo, Pablo; Rubio-Mayo, Paula; Sacchi, Paolo; Sáez, Carlos; Salamanca, Elisa; Sanchez-Pinto, L. Nelson; Sandrin, Arnaud; Santhanam, Nandhini; Santos, Janaina C. C.; Sanz Vidorreta, Fernando J.; Savino, Maria; Schubert, Petra; Schuettler, Juergen; Scudeller, Luigia; Sebire, Neil J.; Serrano-Balazote, Pablo; Serre, Patricia; Serret-Larmande, Arnaud; Shah, Mohsin; Hossein Abad, Zahra Shakeri; Silvio, Domenick; Sliz, Piotr; Son, Jiyeon; Sonday, Charles; Sperotto, Francesca; Spiridou, Anastasia; Strasser, Zachary H.; Tanni, Suzana E.; Taylor, Deanne M.; Terriza-Torres, Ana I.; Toh, Emma M. S.; Torti, Carlo; Trecarichi, Enrico M.; Vallejos, Andrew K.; Varoquaux, Gael; Vella, Margaret E.; Vie, Jill-Jênn; Vitacca, Michele; Wagholikar, Kavishwar B.; Waitman, Lemuel R.; Wang, Xuan; Wassermann, Demian; Wolkewitz, Martin; Wong, Scott; Xiong, Xin; Ye, Ye; Yehya, Nadir; Zachariasse, Joany M.; Zahner, Janet J.; Zambelli, Alberto; Zuccaro, Valentina; Zucco, Chiara |
| Contributors: |
Tan, Byorn W. L.; Tan, Bryce W. Q.; Tan, Amelia L. M.; Schriver, Emily R.; Gutiérrez-Sacristán, Alba; Das, Priyam; Yuan, William; Hutch, Meghan R.; García Barrio, Noelia; Pedrera Jimenez, Miguel; Abu-el-rub, Noor; Morris, Michele; Moal, Bertrand; Verdy, Guillaume; Cho, Kelly; Yuk-Lam, Ho; Patel, Lav P.; Dagliati, Arianna; Neuraz, Antoine; Klann, Jeffrey G.; South, Andrew M.; Visweswaran, Shyam; Hanauer, David A.; Maidlow, Sarah E.; Liu, Mei; Mowery, Danielle L.; Batugo, Ashley; Makoudjou, Adeline; Tippmann, Patric; Zöller, Daniela; Brat, Gabriel A.; Luo, Yuan; Avillach, Paul; Bellazzi, Riccardo; Chiovato, Luca; Malovini, Alberto; Tibollo, Valentina; Samayamuthu, Malarkodi Jebathilagam; Serrano Balazote, Pablo; Xia, Zongqi; Loh, Ne Hooi Will; Chiudinelli, Lorenzo; Bonzel, Clara-Lea; Hong, Chuan; Zhang, Harrison G.; Weber, Griffin M.; Kohane, Isaac S.; Cai, Tianxi; Omenn, Gilbert S.; Holmes, John H.; Ngiam, Kee Yuan; Aaron, James R.; Agapito, Giuseppe; Albayrak, Adem; Albi, Giuseppe; Alessiani, Mario; Alloni, Anna; Amendola, Danilo F.; Angoulvant, Françoi; Anthony, Li L. L. J.; Aronow, Bruce J.; Ashraf, Fatima; Atz, Andrew; Panickan, Vidul Ayakulangara; Azevedo, Paula S.; Balshi, Jame; Beaulieu-Jones, Brett K.; Beaulieu-Jones, Brendin R.; Bell, Douglas S.; Bellasi, Antonio; Vincent, Benoit; Beraghi, Michele; Bernal-Sobrino, José Lui; Bernaux, Mélodie; Bey, Romain; Bhatnagar, Surbhi; Blanco-Martínez, Alvar; Boeker, Martin; Booth, John; Bosari, Silvano; Bourgeois, Florence T.; Bradford, Robert L.; Bréant, Stéphane; Brown, Nicholas W.; Bruno, Raffaele; Bryant, William A.; Bucalo, Mauro; Bucholz, Emily; Burgun, Anita; Cannataro, Mario; Carmona, Aldo; Cattelan, Anna Maria; Caucheteux, Charlotte; Champ, Julien |
| Publication Year: |
2023 |
| Collection: |
IRIS UNIPV (Università degli studi di Pavia) |
| Subject Terms: |
Acute kidney injury; COVID-19; Chronic kidney disease; Electronic health record; SARS-CoV-2 |
| Description: |
Background While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking.Methods A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1-365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021.Findings Advanced age (HR 2.77, 95%CI 2.53-3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03-4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55-5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14-1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37-0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17-1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20-1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45-1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80-13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10-1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32-1.67) and 365 days (RR 1.54, 95%CI 1.21-1.96) compared to COVID-19 patients with no AKI.Interpretation COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Copyright (C) 2022 Published by Elsevier Ltd. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36381999; info:eu-repo/semantics/altIdentifier/wos/WOS:000898807700006; volume:55; firstpage:101724; journal:ECLINICALMEDICINE; https://hdl.handle.net/11571/1491983 |
| DOI: |
10.1016/j.eclinm.2022.101724 |
| Availability: |
https://hdl.handle.net/11571/1491983; https://doi.org/10.1016/j.eclinm.2022.101724 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.C9EFED16 |
| Database: |
BASE |