| Title: |
The serum oestradiol/progesterone ratio on the day of OPU + 7, but not the day of OPU + 5, affects the rates of live birth in fresh blastocyst embryo transfer cycles |
| Authors: |
Zhao, Wenxian; Diao, Honglu; Chen, Xin; Xu, Shaoyuan; Jiang, Shengfang; Cao, Hong; Zhang, Changjun; Zhang, Ying |
| Contributors: |
Innovative Research Program for Graduates of Hubei University of Medicine; Innovation Group of Natural Science Foundation of Hubei Province; Principal Investigator Grant of Biomedical Research Institute of Hubei University of Medicine; Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research; National Natural Science Foundation of China; Scientific Technological Project of Shiyan City of Hubei Province |
| Source: |
Journal of Ovarian Research ; volume 16, issue 1 ; ISSN 1757-2215 |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2023 |
| Description: |
Background In an in vitro fertilization (IVF) cycle, the embryo ends its wandering time and begins the process of implantation into the uterine cavity on the seventh day after oocyte pick-up (OPU + 7), which is closer than OPU + 5 to the time of nidation. Therefore, measuring the oestradiol (E2)/progesterone (P) ratio on OPU + 7 may be helpful for predicting pregnancy outcomes. Methods This is a retrospective cohort study of 2,257 women undergoing a follicular-phase depot gonadotropin-releasing hormone agonist (GnRH-a) protocol for in vitro fertilization /intracytoplasmic sperm injection (IVF/ICSI) treatment and fresh blastocyst embryo transfer cycles at a university-affiliated fertility center between January 2016 and April 2021. First, 2,257 women were split into two groups based on clinical pregnancy for analyzing the levels of E 2 and P and the E 2 /P ratio on the day of OPU + 2, OPU + 5 and OPU + 7. And then 2,257 cycles were stratified into three groups based on E 2 /P ratio tertiles on OPU + 7: the low group (1.3–15.7 pg/ng), middle group (15.7–28.8 pg/ng), and high group (28.8–487.2 pg/ng). The threshold effect of the E 2 /P ratio on OPU + 7 on live birth was investigated using a two-piecewise linear regression model and a smoothing function curve. Results The level of P in the clinical pregnancy group were lower than that in the nonclinical pregnancy group on both OPU + 2 and OPU + 7 (201.9 ± 71.6 ng/ml vs 213.1 ± 77.6 ng/ml, 89.5 ± 88.5 ng/ml vs 99.5 ± 94.9 ng/ml, P < 0.05). The E 2 /P ratio in the clinical pregnancy group were higher than that in the nonclinical pregnancy group on both OPU + 2 and OPU + 7 (8.4 ± 6.5 pg/ng vs 8.0 ± 6.8 pg/ng, 32.3 ± 38.5 pg/ng vs 25.2 ± 31.0 pg/ng, P < 0.01). The E 2 /P ratio on OPU + 7 was positively associated with positive hCG (adjusted OR = 1.01; 95% CI, 1.01–1.02; P < 0.0001), clinical pregnancy (adjusted OR = 1.01; 95% CI, 1.00–1.01; P = 0.0067) and live birth (adjusted OR = 1.01; 95% CI, 1.00–1.01; P < 0.001), and a nonlinear correlation was ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s13048-023-01096-3 |
| DOI: |
10.1186/s13048-023-01096-3.pdf |
| DOI: |
10.1186/s13048-023-01096-3/fulltext.html |
| Availability: |
http://dx.doi.org/10.1186/s13048-023-01096-3; https://link.springer.com/content/pdf/10.1186/s13048-023-01096-3.pdf; https://link.springer.com/article/10.1186/s13048-023-01096-3/fulltext.html |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.CA0CCAD0 |
| Database: |
BASE |