| Title: |
Responders and non-responders to topical capsaicin display distinct temporal summation of pain profiles |
| Authors: |
Strutton, P; Wong, F; Reddy, A; Rho, Y; Vollert, J; Hughes, S |
| Source: |
8 ; 1 |
| Publisher Information: |
Lippincott, Williams & Wilkins |
| Publication Year: |
2023 |
| Collection: |
Imperial College London: Spiral |
| Description: |
Introduction: Topical application of capsaicin can produce an ongoing pain state in healthy participants. However, approximately one-third report no pain response (ie, nonresponders), and the reasons for this are poorly understood. Objectives: In this study, we investigated temporal summation of pain (TSP) profiles, pain ratings and secondary hyperalgesia responses in responders and nonresponders to 1% topical capsaicin cream. Methods: Assessments were made at baseline and then during an early (ie, 15 minutes) and late (ie, 45 minutes) time points post-capsaicin in 37 healthy participants. Results: Participants reporting a visual analogue scale (VAS) rating of >50 were defined as responders (n = 24) and those with |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
PAIN Reports; http://hdl.handle.net/10044/1/102906 |
| DOI: |
10.1097/PR9.0000000000001071 |
| Availability: |
http://hdl.handle.net/10044/1/102906; https://doi.org/10.1097/PR9.0000000000001071 |
| Rights: |
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.CA431EFA |
| Database: |
BASE |