Psychological and Clinical Factors Mediate Post-COVID-19 Irritable Bowel Syndrome
| Title: | Psychological and Clinical Factors Mediate Post-COVID-19 Irritable Bowel Syndrome |
|---|---|
| Authors: | Hod K; Marasco G; Colecchia L; Cremon C; Barbaro MR; Cacciari G; Falangone F; Kagramanova A; Bordin D; Drug V; Miftode E; Fusaroli P; Mohamed SY; Ricci C; Bellini M; Rahman MM; Melcarne L; Santos J; Lobo B; Bor S; Yapali S; Akyol D; Sapmaz FP; Urun YY; Eskazan T; Celebi A; Kacmaz H; Ebik B; Binicier HC; Bugdayci MS; Yağcı MB; Pullukcu H; Kaya BY; Tureyen A; Hatemi İ; Koc ES; Sirin G; Calıskan AR; Bengi G; Alıs EE; Lukic S; Trajkovska M; Dumitrascu D; Pietrangelo A; Corradini E; Simren M; Sjolund J; Tornkvist N; Ghoshal UC; Kolokolnikova O; Colecchia A; Serra J; Maconi G; De Giorgio R; Danese S; Portincasa P; Di Sabatino A; Maggio M; Philippou E; Lee YY; Salvi D; Venturi A; Borghi C; Zoli M; Gionchetti P; Viale P; Stanghellini V; Barbara G; GI‐COVID19 study group. |
| Contributors: | Hod K; Marasco G; Colecchia L; Cremon C; Barbaro Mr; Cacciari G; Falangone F; Kagramanova A; Bordin D; Drug V; Miftode E; Fusaroli P; Mohamed Sy; Ricci C; Bellini M; Rahman Mm; Melcarne L; Santos J; Lobo B; Bor S; Yapali S; Akyol D; Sapmaz Fp; Urun Yy; Eskazan T; Celebi A; Kacmaz H; Ebik B; Binicier Hc; Bugdayci M; Yağcı, Mb; Pullukcu H; Kaya By; Tureyen A; Hatemi İ; Koc E; Sirin G; Calıskan Ar; Bengi G; Alıs Ee; Lukic S; Trajkovska M; Dumitrascu D; Pietrangelo A; Corradini E; Simren M; Sjolund J; Tornkvist N; Ghoshal Uc; Kolokolnikova O; Colecchia A; Serra J; Maconi G; De Giorgio R; Danese S; Portincasa P; Di Sabatino A; Maggio M; Philippou E; Lee Yy; Salvi D; Venturi A; Borghi C; Zoli M; Gionchetti P; Viale P; Stanghellini V; Barbara G; GI‐COVID19 study Group. |
| Publication Year: | 2025 |
| Collection: | Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| Subject Terms: | Keywords: COVID‐19; depression; dyspnea; gastrointestinal symptom; irritable bowel syndrome; mediation analysis |
| Description: | Background: Exposure to COVID-19 has been shown previously to be associated with a higher risk for irritable bowel syndrome (IBS). This study aimed to better explain this relationship using mediation analysis. Methods: This post hoc analysis of a multicenter cohort study includes 623 patients with and without COVID-19 infection. All participants completed the ROME IV criteria, gastrointestinal symptom rating scale (GSRS), and hospital anxiety and depression scale (HADS) over 1 year. Mediation analysis utilized the PROCESS macro and Baron and Kenny's method for parametric and nonparametric mediating variables, respectively. Key results: The impact of COVID-19 on the development of post-COVID-19 IBS is completely mediated by dyspnea at baseline (adjusted OR = 3.561, p = 0.012), severity of acid regurgitation at 1 month [indirect effect, log-odds metric = 0.090, 95% CI (0.006-0.180)], hunger pains at 1 [indirect effect, log-odds metric = 0.094, 95% CI (0.024-0.178)], and 6 months [indirect effect, log-odds metric = 0.074, 95% CI (0.003-0.150)], depression at 6 [indirect effect, log-odds metric = 0.106, 95% CI (0.009-0.225)] and 12 months [indirect effect, log-odds metric = 0.146, 95% CI (0.016-0.311)] as well as borborygmus [indirect effect, log-odds metric = 0.095, 95% CI (0.009-0.203)], abdominal distention [indirect effect, log-odds metric = 0.162, 95% CI (0.047-0.303)], and increased flatus [indirect effect, log-odds metric = 0.110, 95% CI (0.005-0.234)] at 12 months. Conclusions and inferences: Our findings provide evidence for psychological and clinical mediators between COVID-19 and post-COVID-19 IBS, which may be promising targets for interventions tailored for treating or preventing depression. The presence of specific GI symptoms at COVID-19 onset and their persistence should increase awareness of a potential new onset of IBS diagnosis. K |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40375581; info:eu-repo/semantics/altIdentifier/wos/WOS:001488788000001; volume:15; firstpage:1; lastpage:11; numberofpages:11; journal:NEUROGASTROENTEROLOGY & MOTILITY; https://hdl.handle.net/11379/626765 |
| DOI: | 10.1111/nmo.70079 |
| Availability: | https://hdl.handle.net/11379/626765; https://doi.org/10.1111/nmo.70079 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.CA4DAA0C |
| Database: | BASE |