| Title: |
Associations between hormone therapy use and tau accumulation in brain regions vulnerable to Alzheimer’s disease |
| Authors: |
Coughlan, Gillian T; Rubinstein, Zoe; Klinger, Hannah; Lopez, Kelly A; Hsieh, Stephaine; Boyle, Rory; Seto, Mabel; Townsend, Diana; Mayblyum, Danielle; Thibault, Emma; Jacobs, Heidi IL; Farrell, Michelle; Rabin, Jennifer S; Papp, Kate; Amariglio, Rebecca; Baker, Suzanne; Lois, Cristina; Rentz, Dorene; Price, Julie; Schultz, Aaron; Properzi, Michael; Johnson, Keith; Sperling, Reisa; Buckley, Rachel F |
| Source: |
Science Advances, vol 11, iss 10 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2025 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
5202 Biological Psychology (for-2020); 32 Biomedical and Clinical Sciences (for-2020); 52 Psychology (for-2020); Alzheimer's Disease (rcdc); Neurosciences (rcdc); Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) (rcdc); Dementia (rcdc); Brain Disorders (rcdc); Clinical Research (rcdc); Aging (rcdc); Estrogen (rcdc); Neurodegenerative (rcdc); Women's Health (rcdc); Biomedical Imaging (rcdc); Acquired Cognitive Impairment (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Neurological (hrcs-hc); Humans (mesh); Alzheimer Disease (mesh); tau Proteins (mesh); Female (mesh); Aged (mesh); Middle Aged (mesh); Aged; 80 and over (mesh); Brain (mesh); Positron-Emission Tomography (mesh); Amyloid beta-Peptides (mesh); Estrogen Replacement Therapy (mesh); Hormone Replacement Therapy (mesh) |
| Time: |
eadt1288 |
| Description: |
Elucidating the downstream impact of exogenous hormones on the aging brain will have far-reaching consequences for understanding why Alzheimer's disease (AD) predominates in women almost twofold over men. We tested the extent to which menopausal hormone therapy (HT) use is associated with later-life amyloid-β (Aβ) and tau accumulation using PET on N=146 baseline clinically normal women, aged 51 to 89 years. Women were scanned over a 4.5-year (SD, 2.1; range, 1.3 to 10.4) and 3.5-year (SD, 1.5; range, 1.2 to 8.1) period for Aβ and tau, respectively, ~14 years after the initiation of HT. In older women (aged >70 years), HT users exhibited faster regional tau accumulation relative to non-users, localized to the entorhinal cortex and the inferior temporal and fusiform gyri, with an indirect effect of HT on cognitive decline through regional tau accumulation. In younger women (aged |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt0586s8g8; https://escholarship.org/uc/item/0586s8g8; https://escholarship.org/content/qt0586s8g8/qt0586s8g8.pdf |
| DOI: |
10.1126/sciadv.adt1288 |
| Availability: |
https://escholarship.org/uc/item/0586s8g8; https://escholarship.org/content/qt0586s8g8/qt0586s8g8.pdf; https://doi.org/10.1126/sciadv.adt1288 |
| Rights: |
CC-BY-NC |
| Accession Number: |
edsbas.CA648929 |
| Database: |
BASE |