| Title: |
Impact of different blood group incompatibilities in kidney transplantation: a 15-year outcomes analysis from a large kidney transplant center |
| Authors: |
Obeid, Dalia A.; Broering, Dieter C.; AlMeshari, Khalid A.; Shah, Yaser Z.; Aleid, Hassan A.; AlManea, Hadeel M.; AlAbassi, Amira M.; AlMozain, Nour; Marquez, Kris; Alsaadi, Eman A.; Ali, Tariq Z. |
| Source: |
Frontiers in Transplantation ; volume 4 ; ISSN 2813-2440 |
| Publisher Information: |
Frontiers Media SA |
| Publication Year: |
2025 |
| Collection: |
Frontiers (Publisher - via CrossRef) |
| Description: |
Background While ABO-incompatible kidney transplantation (ABOiKT) has demonstrated favorable short-term outcomes, data on its long-term effects remain limited. This study evaluated the short- and long-term clinical outcomes of ABOiKT across various ABO-incompatible donor–recipient combinations. Methods We included patients who underwent ABOiKT at our institution in 2007–2024. The outcomes assessed included 15-year data on graft, patient survival, and early AMR rates. Results Of 239 ABOiKT cases, AMR occurred in 9.2% and was linked to longer hospitalization and higher graft failure. AMR was most frequent in B–O (20.3%) and A1–O (13.3%) transplants but no cases of AMR were observed in the recipients of kidneys from A2 donors. B to O mismatch significantly increased the risk of AMR-related graft loss. Patient survival was 99.1% at 1 year and 86.2% at 15 years and Graft survival was 92.7% and 87.5% respectively. Conclusions Our study showed favorable outcomes of ABOiKT across different mismatch types. As the largest ABOiKT study in the Middle East with extended follow-up, our study provides important regional insights and contribute significantly to the global understanding of ABOiKT outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.3389/frtra.2025.1690999 |
| DOI: |
10.3389/frtra.2025.1690999/full |
| Availability: |
https://doi.org/10.3389/frtra.2025.1690999; https://www.frontiersin.org/articles/10.3389/frtra.2025.1690999/full |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.CA705B82 |
| Database: |
BASE |