Cerebrospinal fluid cytokine levels affect electroencephalographic activity in Alzheimer's disease
| Title: | Cerebrospinal fluid cytokine levels affect electroencephalographic activity in Alzheimer's disease |
|---|---|
| Authors: | Bruno, Matilde; Bonomi, Chiara Giuseppina; Castelli, Alessandro; Izzi, Francesca; Placidi, Fabio; Falletti, Silvia; Mercuri, Nicola Biagio; Motta, Caterina; Martorana, Alessandro |
| Contributors: | Ministero della Salute |
| Source: | Journal of Alzheimer's Disease Reports ; volume 9 ; ISSN 2542-4823 2542-4823 |
| Publisher Information: | SAGE Publications |
| Publication Year: | 2025 |
| Description: | To investigate the role of neuroinflammation as mediator of amyloid-β-induced cortical activity changes in Alzheimer's disease (AD), we examined the relationship between cerebrospinal fluid (CSF) inflammatory cytokines (IL-1β, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, TNF-α, IFN-γ, GM-CSF, G-CSF, MIP-1α, MCP-1) and electroencephalographic (EEG) abnormalities in a cohort of biologically defined AD patients (n = 55, M:F = 19:36, median age 73, Mini-Mental State Examination ≥ 22). We retrieved a positive association between IL-4 CSF levels and EEG background activity frequency; IL-7, IL-8, and IL-12 CSF levels were positively associated with the presence of interictal epileptiform discharges. Neuroinflammation accompanying AD pathology may enhance the amyloid's epileptogenic potential while also counteracting neurodegenerative damage. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| DOI: | 10.1177/25424823241306772 |
| Availability: | https://doi.org/10.1177/25424823241306772; https://journals.sagepub.com/doi/pdf/10.1177/25424823241306772; https://journals.sagepub.com/doi/full-xml/10.1177/25424823241306772 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ ; https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: | edsbas.CADF6C18 |
| Database: | BASE |