| Title: |
What have we learned from recent twin studies about the etiology of neurodevelopmental disorders? |
| Authors: |
Posthuma, Daniëlle; Polderman, TJC |
| Source: |
Posthuma, D & Polderman, TJC 2013, 'What have we learned from recent twin studies about the etiology of neurodevelopmental disorders?', Current Opinion in Neurology, vol. 26, no. 2, pp. 111-121. https://doi.org/10.1097/WCO.0b013e32835f19c3 |
| Publication Year: |
2013 |
| Subject Terms: |
/dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES045501; name=EMC NIHES-04-55-01 |
| Description: |
Purpose of review The relative influence of genes and environment on the liability to neurodevelopmental disorders (NDDs) can be investigated using a twin design. This review highlights the results of the most recent twin studies of NDDs. Recent findings Recent twin studies have confirmed that NDDs show moderate-to-high heritability, and that from an etiological viewpoint both autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are best regarded as the extremes on a continuous liability distribution. Both ASD and ADHD show high heritability in childhood and a substantial drop in heritability in adulthood, which is likely explained by the use of different assessment strategies in childhood versus adulthood, or by a Summary The findings of twin studies implicate substantial heritability of NDDs, and warrant large-scale molecular genetic studies for such traits. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
1350-7540; 1473-6551 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/23426380; info:eu-repo/semantics/altIdentifier/pissn/1350-7540; info:eu-repo/semantics/altIdentifier/eissn/1473-6551 |
| DOI: |
10.1097/WCO.0b013e32835f19c3 |
| Availability: |
https://pure.eur.nl/en/publications/a4015f7a-4446-4d28-b5cb-11ed98180c4b; https://doi.org/10.1097/WCO.0b013e32835f19c3; https://hdl.handle.net/1765/39340 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.CAFF9B50 |
| Database: |
BASE |