Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study
| Title: | Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study |
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| Authors: | Marasco G.; Cremon C.; Barbaro M. R.; Salvi D.; Cacciari G.; Kagramanova A.; Bordin D.; Drug V.; Miftode E.; Fusaroli P.; Mohamed S. Y.; Ricci C.; Bellini M.; Rahman M. M.; Melcarne L.; Santos J.; Lobo B.; Bor S.; Yapali S.; Akyol D.; Sapmaz F. P.; Urun Y. Y.; Eskazan T.; Celebi A.; Kacmaz H.; Ebik B.; Binicier H. C.; Bugdayci M. S.; Yagci M. B.; Pullukcu H.; Kaya B. Y.; Tureyen A.; Hatemi I.; Koc E. S.; Sirin G.; Caliskan A. R.; Bengi G.; Alis E. E.; Lukic S.; Trajkovska M.; Hod K.; Dumitrascu D.; Pietrangelo A.; Corradini E.; Simren M.; Sjolund J.; Tornkvist N.; Ghoshal U. C.; Kolokolnikova O.; Colecchia A.; Serra J.; Maconi G.; De Giorgio R.; Danese S.; Portincasa P.; Di Stefano M.; Maggio M.; Philippou E.; Lee Y. Y.; Venturi A.; Borghi C.; Zoli M.; Gionchetti P.; Viale P.; Stanghellini V.; Barbara G.; Piacentini A.; Shengelia M.; Vechorko V.; Cardamone C.; Rosei C. A.; Pancetti A.; Rettura F.; Pedrosa M.; Campoli C.; Mijac D.; Korac M.; Karic U.; Markovic A.; Najdeski A.; Nikolova D.; Dimzova M.; Lior O.; Shinhar N.; Perelmutter O.; Ringel Y.; Sabo C. M.; Chis A.; Bonucchi G.; Caio G. P. I.; Ghirardi C.; Marziani B.; Rizzello B.; Aguilar A.; Capogreco A.; Aghemo A.; Di Paolo D. M.; Marconi G.; Di Sabatino A.; Tagliaferri S.; Naves J. E.; Galli A.; Dragoni G.; Nedelcu L.; Mauloni P. A.; Del Vecchio S.; Rotondo L.; Capuani F.; Montanari D.; Palombo F.; Paone C.; Mastel G.; Fontana C.; Bellacosa L.; Cogliandro R. F. |
| Contributors: | Marasco, G.; Cremon, C.; Barbaro, M. R.; Salvi, D.; Cacciari, G.; Kagramanova, A.; Bordin, D.; Drug, V.; Miftode, E.; Fusaroli, P.; Mohamed, S. Y.; Ricci, C.; Bellini, M.; Rahman, M. M.; Melcarne, L.; Santos, J.; Lobo, B.; Bor, S.; Yapali, S.; Akyol, D.; Sapmaz, F. P.; Urun, Y. Y.; Eskazan, T.; Celebi, A.; Kacmaz, H.; Ebik, B.; Binicier, H. C.; Bugdayci, M. S.; Yagci, M. B.; Pullukcu, H.; Kaya, B. Y.; Tureyen, A.; Hatemi, I.; Koc, E. S.; Sirin, G.; Caliskan, A. R.; Bengi, G.; Alis, E. E.; Lukic, S.; Trajkovska, M.; Hod, K.; Dumitrascu, D.; Pietrangelo, A.; Corradini, E.; Simren, M.; Sjolund, J.; Tornkvist, N.; Ghoshal, U. C.; Kolokolnikova, O.; Colecchia, A.; Serra, J.; Maconi, G.; De Giorgio, R.; Danese, S.; Portincasa, P.; Di Stefano, M.; Maggio, M.; Philippou, E.; Lee, Y. Y.; Venturi, A.; Borghi, C.; Zoli, M.; Gionchetti, P.; Viale, P.; Stanghellini, V.; Barbara, G.; Piacentini, A.; Shengelia, M.; Vechorko, V.; Cardamone, C.; Rosei, C. A.; Pancetti, A.; Rettura, F.; Pedrosa, M.; Campoli, C.; Mijac, D.; Korac, M.; Karic, U.; Markovic, A.; Najdeski, A.; Nikolova, D.; Dimzova, M.; Lior, O.; Shinhar, N.; Perelmutter, O.; Ringel, Y.; Sabo, C. M.; Chis, A.; Bonucchi, G.; Caio, G. P. I.; Ghirardi, C.; Marziani, B.; Rizzello, B.; Aguilar, A.; Capogreco, A.; Aghemo, A.; Di Paolo, D. M.; Marconi, G.; Di Sabatino, A.; Tagliaferri, S. |
| Publication Year: | 2022 |
| Collection: | Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: | COVID-19; Gastroenteritis; SARS-CoV-2; Prospective Studies; Interviews as Topic; Surveys and Questionnaires |
| Description: | INTRODUCTION: Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated with their occurrence, and variation at 1 month. METHODS: TheGI-COVID-19 is a prospective,multicenter, controlled study. Patientswith and without COVID-19 diagnosis were recruited at hospital admission and asked for GI symptoms at admission and after 1 month, using the validated Gastrointestinal Symptom Rating Scale questionnaire. RESULTS: The study included 2036 hospitalized patients. A total of 871 patients (575 COVID1and 296 COVID2) were included for the primary analysis. GI symptoms occurred more frequently in patients with COVID-19 (59.7%; 343/575 patients) than in the control group (43.2%; 128/296 patients) (P < 0.001). Patients with COVID-19 complained of higher presence or intensity of nausea, diarrhea, loose stools, and urgency as compared with controls. At a 1-month follow-up, a reduction in the presence or intensity of GI symptoms was found in COVID-19 patients with GI symptoms at hospital admission. Nausea remained increased over controls. Factors significantly associated with nausea persistence in COVID-19 were female sex, high body mass index, the presence of dyspnea, and increased C-reactive protein levels. DISCUSSION: The prevalence of GI symptoms in hospitalized patients with COVID-19 is higher than previously reported. Systemic and respiratory symptoms are often associated with GI complaints. Nausea may persist after the resolution of COVID-19 infection. |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34751672; info:eu-repo/semantics/altIdentifier/wos/WOS:000738773800023; volume:117; issue:1; firstpage:147; lastpage:157; numberofpages:11; journal:THE AMERICAN JOURNAL OF GASTROENTEROLOGY; https://hdl.handle.net/11392/2490257; https://journals.lww.com/ajg/fulltext/2022/01000/prevalence_of_gastrointestinal_symptoms_in_severe.24.aspx |
| DOI: | 10.14309/ajg.0000000000001541 |
| Availability: | https://hdl.handle.net/11392/2490257; https://doi.org/10.14309/ajg.0000000000001541; https://journals.lww.com/ajg/fulltext/2022/01000/prevalence_of_gastrointestinal_symptoms_in_severe.24.aspx |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.CB1B80C0 |
| Database: | BASE |