| Title: |
Landscape of Subcutaneous Administration Strategies for Monoclonal Antibodies in Oncology |
| Authors: |
Jacquot, Guillaume; Lopez Navarro, Pedro; Grange, Coralie; Boudali, Lotfi; Harlepp, Sébastien; Pivot, Xavier; Detappe, Alexandre |
| Contributors: |
Institut de Cancérologie de Strasbourg Europe (ICANS); Équipe labellisée Ligue Contre le Cancer Strasbourg; Ligue Nationale Contre le Cancer (LNCC); Institut du Médicament de Strasbourg (IMS Strasbourg ); Institut Pluridisciplinaire Hubert Curien (IPHC); Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS); ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010); ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020); European Project: 950101,ERC-2020-STG,ERC-2020-STG,theranoimmuno(2021); European Project: 101138078,ERC-2023-POC,ERC-2023-POC,Sub-NK(2024) |
| Source: |
ISSN: 0935-9648. |
| Publisher Information: |
CCSD; Wiley-VCH Verlag |
| Publication Year: |
2024 |
| Collection: |
HAL-IN2P3 (Institut national de physique nucléaire et de physique des particules) |
| Subject Terms: |
intravenous; oncology; polymer; subcutaneous; antibodies; antibodies intravenous oncology polymer subcutaneous; [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; In recent decades, subcutaneous (SC) administration of monoclonal antibodies (mAbs) has emerged as a promising alternative to intravenous delivery in oncology, offering comparable therapeutic efficacy while addressing patient preferences. This perspective article provides an in-depth analysis of the technological landscape surrounding SC mAb administration in oncology. It outlines various technologies under evaluation across developmental stages, spanning from preclinical investigations to the integration of established methodologies in clinical practice. Additionally, this perspective article explores emerging trends and prospective trajectories, shedding light on the evolving landscape of SC mAb administration. Furthermore, it emphasizes key checkpoints related to quality attributes essential for optimizing mAb delivery via the SC route. This review serves as a valuable resource for researchers, clinicians, and healthcare policymakers, offering insights into the advancement of SC mAb administration in oncology and its implications for patient care. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement//950101/EU/Theranostic Immune Cell/theranoimmuno; info:eu-repo/grantAgreement//101138078/EU/Subcutaneous delivery of theranostic cell-based therapies/Sub-NK |
| DOI: |
10.1002/adma.202406604 |
| Availability: |
https://hal.science/hal-04886434; https://hal.science/hal-04886434v1/document; https://hal.science/hal-04886434v1/file/Advanced%20Materials%20-%202024%20-%20Jacquot%20-%20Landscape%20of%20Subcutaneous%20Administration%20Strategies%20for%20Monoclonal%20Antibodies%20in.pdf; https://doi.org/10.1002/adma.202406604 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.CB235BE5 |
| Database: |
BASE |