| Title: |
What’s new on giant cell tumor of bone |
| Authors: |
Tsukamoto, Shinji; Errani, Costantino; Balach, Tessa; Zamora, Tomas; Ortiz-Cruz, Eduardo; Rajasekaran, Raja Bhaskara; Yau, Raymond; Ji, Tao; Pérez-Muñoz, Israel; Linares, Francisco; Angelini, Andrea; Ruggieri, Pietro; Benevenia, Joseph; Mavrogenis, Andreas F. |
| Contributors: |
Tsukamoto, Shinji; Errani, Costantino; Balach, Tessa; Zamora, Toma; Ortiz-Cruz, Eduardo; Rajasekaran, Raja Bhaskara; Yau, Raymond; Ji, Tao; Pérez-Muñoz, Israel; Linares, Francisco; Angelini, Andrea; Ruggieri, Pietro; Benevenia, Joseph; Mavrogenis, Andreas F. |
| Publication Year: |
2026 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Curettage; Denosumab; Giant cell tumor of bone; RFA; Recurrence; TRACP 5b |
| Description: |
When treating extremities affected by giant cell tumor of bone (GCTB), curettage should be performed to preserve the joint as much as possible in order to obtain a good functional outcome. The local recurrence risk is high following curettage, but new techniques are being developed to reduce local recurrence. We present a review of the literature reporting favorable results of radiofrequency ablation alone in locally recurrent small GCTB. New filling materials are also being developed to prevent non-oncological complications such as arthrosis and fractures. Routine measurement of tartrate-resistant acid phosphatase 5b in serum may be helpful in detecting early instances of local recurrence. For unresectable or metastatic GCTB, there is an urgent need for a new drug that is as effective as denosumab, avoids side effects, and can be administered to pregnant women. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41568883; volume:12; firstpage:2; lastpage:2; numberofpages:1; journal:SICOT-J; https://hdl.handle.net/11577/3576108 |
| DOI: |
10.1051/sicotj/2025063 |
| Availability: |
https://hdl.handle.net/11577/3576108; https://doi.org/10.1051/sicotj/2025063 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.CB8C49C5 |
| Database: |
BASE |