| Title: |
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| Authors: |
Guerreiro, R; Escott-Price, V; Darwent, L; Parkkinen, L; Ansorge, O; Hernandez, DG; Nalls, MA; Clark, L; Honig, L; Marder, K; van der Flier, W; Holstege, H; Louwersheimer, E; Lemstra, A; Scheltens, P; Rogaeva, E; St George-Hyslop, P; Londos, E; Zetterberg, H; Ortega-Cubero, S; Pastor, P; Ferman, TJ; Graff-Radford, NR; Ross, OA; Barber, I; Braae, A; Brown, K; Morgan, K; Maetzler, W; Berg, D; Troakes, C; Al-Sarraj, S; Lashley, T; Compta, Y; Revesz, T; Lees, A; Cairns, NJ; Halliday, GM; Mann, D; Pickering-Brown, S; Powell, J; Lunnon, K; Lupton, MK; International Parkinson's Disease Genomics Consortium (IPDGC); Dickson, D; Hardy, J; Singleton, A; Bras, J |
| Publisher Information: |
Elsevier |
| Publication Year: |
2016 |
| Collection: |
University of Exeter: Open Research Exeter (ORE) |
| Subject Terms: |
Alzheimer's disease; Dementia with Lewy bodies; Genetic correlation; Parkinson's disease |
| Description: |
This is the final version of the article. Available from the publisher via the DOI in this record. ; Open Access funded by Wellcome Trust ; The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. ; Rita Guerreiro and Jose Bras are supported by Research Fellowships from the Alzheimer's Society. This work was supported in part by a Parkinson's UK Innovation Award (K-1204) in collaboration with the Lewy Body Society and by the Wellcome Trust/MRC Joint Call in Neurodegeneration award (WT089698) to the UK Parkinson's Disease Consortium whose members are from the UCL Institute of Neurology, the University of Sheffield, and the MRC Protein Phosphorylation Unit at the University of Dundee and by an anonymous Foundation. The authors would like to acknowledge Elena Lorenzo for her technical assistance. This study was supported in part by grants from the Spanish Ministry of Science and InnovationSAF2006-10126 (2006–2009) and SAF2010-22329-C02-01 (2011–2013) and SAF2013-47939-R (2013–2015) to Pau Pastor and by the UTE project FIMA to Pau Pastor. They acknowledge the Oxford Brain Bank, supported by the Medical Research Council (MRC), Brains for Dementia Research (BDR) (Alzheimer Society and Alzheimer Research UK), Autistica UK, and the NIHR Oxford Biomedical Research Centre. The sample collection and database of the ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
26643944 |
| Relation: |
http://www.ncbi.nlm.nih.gov/pubmed/26643944; http://hdl.handle.net/10871/20816; Neurobiology of Aging; PMC4759606 |
| DOI: |
10.1016/j.neurobiolaging.2015.10.028 |
| Availability: |
http://hdl.handle.net/10871/20816; https://doi.org/10.1016/j.neurobiolaging.2015.10.028 |
| Rights: |
Open Access Article, licensed under Creative Commons CC-BY licence. |
| Accession Number: |
edsbas.CBA48659 |
| Database: |
BASE |