| Title: |
Ceftazidime-avibactam use for klebsiella pneumoniae carbapenemase-producing k. pneumoniae infections: A retrospective observational multicenter study |
| Authors: |
Tumbarello M.; Raffaelli F.; Giannella M.; Mantengoli E.; Mularoni A.; Venditti M.; De Rosa F. G.; Sarmati L.; Bassetti M.; Brindicci G.; Rossi M.; Luzzati R.; Grossi P. A.; Corona A.; Capone A.; Falcone M.; Mussini C.; Trecarichi E. M.; Cascio A.; Guffanti E.; Russo A.; De Pascale G.; Tascini C.; Gentile I.; Losito A. R.; Bussini L.; Corti G.; Ceccarelli G.; Corcione S.; Compagno M.; Giacobbe D. R.; Saracino A.; Fantoni M.; Antinori S.; Peghin M.; Bonfanti P.; Oliva A.; De Gasperi A.; Tiseo G.; Rovelli C.; Meschiari M.; Shbaklo N.; Spanu T.; Cauda R.; Viale P. |
| Contributors: |
M. Tumbarello; F. Raffaelli; M. Giannella; E. Mantengoli; A. Mularoni; M. Venditti; F.G. De Rosa; L. Sarmati; M. Bassetti; G. Brindicci; M. Rossi; R. Luzzati; P.A. Grossi; A. Corona; A. Capone; M. Falcone; C. Mussini; E.M. Trecarichi; A. Cascio; E. Guffanti; A. Russo; G. De Pascale; C. Tascini; I. Gentile; A.R. Losito; L. Bussini; G. Corti; G. Ceccarelli; S. Corcione; M. Compagno; D.R. Giacobbe; A. Saracino; M. Fantoni; S. Antinori; M. Peghin; P. Bonfanti; A. Oliva; A. De Gasperi; G. Tiseo; C. Rovelli; M. Meschiari; N. Shbaklo; T. Spanu; R. Cauda; P. Viale |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2021 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
Carbapenemase; Ceftazidime-avibactam; KPC-producing Klebsiella pneumoniae; Adult; Anti-Bacterial Agent; Azabicyclo Compound; Bacterial Protein; Ceftazidime; Drug Combination; Human; Microbial Sensitivity Test; Retrospective Studie; beta-Lactamase; Klebsiella Infection; Klebsiella pneumoniae; Settore MED/17 - Malattie Infettive; Settore MEDS-10/B - Malattie infettive |
| Description: |
Background: A growing body of observational evidence supports the value of ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods: We retrospectively analyzed observational data on use and outcomes of CAZ-AVI therapy for infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted for propensity score for receipt of CAZ-AVI combination regimens versus CAZ-AVI monotherapy. Results: The cohort comprised 577 adults with bloodstream infections (n = 391) or nonbacteremic infections involving mainly the urinary tract, lower respiratory tract, and intra-abdominal structures. All received treatment with CAZ-AVI alone (n = 165) or with ≥1 other active antimicrobials (n = 412). The all-cause mortality rate 30 days after infection onset was 25% (146/577). There was no significant difference in mortality between patients managed with CAZ-AVI alone and those treated with combination regimens (26.1% vs 25.0%, P =. 79). In multivariate analysis, mortality was positively associated with presence at infection onset of septic shock (P =. 002), neutropenia (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33618353; info:eu-repo/semantics/altIdentifier/wos/WOS:000720749600210; volume:73; issue:9; firstpage:1664; lastpage:1676; numberofpages:13; journal:CLINICAL INFECTIOUS DISEASES; https://hdl.handle.net/2434/903953 |
| DOI: |
10.1093/cid/ciab176 |
| Availability: |
https://hdl.handle.net/2434/903953; https://doi.org/10.1093/cid/ciab176 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.CBA7C52A |
| Database: |
BASE |