| Title: |
Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease |
| Authors: |
Baron, Rona; Babcock, Alicia A.; Nemirovsky, Anna; Finsen, Bente; Monsonego, Alon |
| Contributors: |
Israel Science Foundation; Danish Medical Research Council; Lundbeck Foundation; The Danish Alzheimer Research Foundation |
| Source: |
Aging Cell ; volume 13, issue 4, page 584-595 ; ISSN 1474-9718 1474-9726 |
| Publisher Information: |
Wiley |
| Publication Year: |
2014 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Summary Microglia integrate within the neural tissue with a distinct ramified morphology through which they scan the surrounding neuronal network. Here, we used a digital tool for the quantitative morphometric characterization of fine cortical microglial structures in mice, and the changes they undergo with aging and in A lzheimer's‐like disease. We show that, compared with microglia in young mice, microglia in old mice are less ramified and possess fewer branches and fine processes along with a slightly increased proinflammatory cytokine expression. A similar microglial pathology appeared 6–12 months earlier in mouse models of A lzheimer's disease ( AD ), along with a significant increase in brain parenchyma lacking coverage by microglial processes. We further demonstrate that microglia near amyloid plaques acquire unique activated phenotypes with impaired process complexity. We thus show that along with a chronic proinflammatory reaction in the brain, aging causes a significant reduction in the capacity of microglia to scan their environment. This type of pathology is markedly accelerated in mouse models of AD , resulting in a severe microglial process deficiency, and possibly contributing to enhanced cognitive decline. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/acel.12210 |
| Availability: |
https://doi.org/10.1111/acel.12210; http://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Facel.12210; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Facel.12210; https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12210; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/acel.12210 |
| Rights: |
http://creativecommons.org/licenses/by/3.0/ |
| Accession Number: |
edsbas.CBCCAC57 |
| Database: |
BASE |