| Title: |
Effects of Erdosteine in Experimental Sepsis Model in Rats |
| Authors: |
Kavakli, H Sahin; Alici, O; Koca, C; Altintas, ND; Aydin, M |
| Source: |
Hong Kong Journal of Emergency Medicine ; volume 18, issue 5, page 282-286 ; ISSN 1024-9079 2309-5407 |
| Publisher Information: |
Wiley |
| Publication Year: |
2011 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objective Erdosteine is a mucolytic agent that is known to possess antioxidant effects. This study investigated the effects of erdosteine on endothelin-1 (ET-1) levels and oxidative stress parameters superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model. Methods Four groups of Wistar albino rats (n=8 per group) were randomly allocated to the following groups: sham (group 1), sepsis (group 2), erdosteine control (group 3) and a sepsis group pretreated with erdosteine (group 4). Sepsis was induced using E. Coli ATCC 25922 inoculation. Serum ET-1, liver tissue SOD and MDA levels were determined in all groups. Results ET-1 levels were significantly higher in group 2 compared to groups 1, 3 and 4 (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/102490791101800503 |
| Availability: |
http://dx.doi.org/10.1177/102490791101800503; http://journals.sagepub.com/doi/pdf/10.1177/102490791101800503 |
| Rights: |
http://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.CBF473B7 |
| Database: |
BASE |