| Title: |
Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span |
| Authors: |
Pearson, Kevin J.; Baur, Joseph A.; Lewis, Kaitlyn N.; Peshkin, Leonid; Price, Nathan L.; Labinskyy, Nazar; Swindell, William R.; Kamara, Davida; Minor, Robin K.; Pérez, Evelin; Jamieson, Hamish A.; Zhang, Yongqing; Dunn, Stephen R.; Sharma, Kumar; Pleshko, Nancy; Woollett, Laura A.; Csiszar, Anna; Ikeno, Yuji; Couteur, David le; Elliott, Peter J.; Becker, Kevin G.; Navas, Plácido; Ingram, Donald K.; Wolf, Norman S.; Ungvari, Zoltan; Sinclair, David A.; Cabo, Rafael de |
| Publisher Information: |
Elsevier |
| Publication Year: |
2008 |
| Collection: |
Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| Subject Terms: |
Antioxidants; Stilbenes; Resveratrol; Gene expression regulation; Aging; Apoptosis; Cardiovascular system; Osteoporosis |
| Description: |
22 páginas, 4 figuras. ; A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife. ; This work was supported by grants from the American Heart Association (0425834T to J.A.B. and 0435140N to A.C.) and from the NIH (RO1GM068072, AG19972, and AG19719 to D.A.S.), (HL077256 to Z.U.), (HD034089 to L.W), (2RO1 EY011733 to N.S.W.), Spanish grant (BFU2005-03017 to P.N.), and by the generous support of Mr. Paul F. Glenn and The Paul F. Glenn Laboratories for the Biological Mechanisms of Aging. ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://dx.doi.org/10.1016/j.cmet.2008.06.011; PMC2538685; PMID: 18599363; NIHMS57083; http://hdl.handle.net/10261/41582 |
| DOI: |
10.1016/j.cmet.2008.06.011 |
| Availability: |
http://hdl.handle.net/10261/41582; https://doi.org/10.1016/j.cmet.2008.06.011 |
| Rights: |
open |
| Accession Number: |
edsbas.CC02BD1B |
| Database: |
BASE |