| Title: |
Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry |
| Authors: |
Scelo, Ghislaine; Torres-Duque, Carlos A.; Maspero, Jorge; Tran, Trung N.; Murray, Ruth; Martin, Neil; Menzies-Gow, Andrew N.; Hew, Mark; Peters, Matthew J.; Gibson, Peter G.; Christoff, George C.; Popov, Todor A.; Côté, Andréanne; Bergeron, Celine; Dorscheid, Delbert; FitzGerald, J. Mark; Chapman, Kenneth R.; Boulet, Louis Philippe; Bhutani, Mohit; Sadatsafavi, Mohsen; Jiménez-Maldonado, Libardo; Duran-Silva, M; Rodriguez, B; Celis-Preciado, CA; Cano-Rosales, DJ; Solarte, I; Fernandez-Sanchez, MJ; Parada-Tovar, P; Bülow, AV; Bjerrum, AS; Ulrik, CS; Assing, KD; Rasmussen, LM; Hansen, S; Altraja, A; Bourdin, A; Taille, C; Charriot, J; Roche, N; Papaioannou, AI; Kostikas, K; Papadopoulos, NG; Salvi, S; Long, D; Mitchell, PD; Costello, R; Sirena, C; Cardini, C; Heffler, E; Puggioni, F; Canonica, GW; Guida, G; Iwanaga, T; Al-Ahmad, M; Linnemann, DL; García, U; Kuna, P; Fonseca, JA; Al-Lehebi, R; Koh Siyue, M; Rhee, CK; Cosio, BG; de Llano, LP; Perng Steve, D-W; Huang, EW-C; Wang, H-C; Tsai, M-J; Mahboub, B; Jaber Salameh, LI; Jackson, D; Busby, J; Heaney, LG; Pfeffer, P; Goddard, AG; Wang, E; Hoyte, F; Wechsler, ME; Chapman, N; Katial, R; Carter, V; Bulathsinhala, L; Eleangovan, N; Ariti, C; Lyu, J; Price, D; Porsbjerg, C |
| Contributors: |
The University of Newcastle. College of Health, Medicine & Wellbeing, School of Medicine and Public Health |
| Publisher Information: |
Elsevier |
| Publication Year: |
2024 |
| Collection: |
NOVA: The University of Newcastle Research Online (Australia) |
| Subject Terms: |
asthma; prevalence; multimorbidity; adult patients; SDG 3; Sustainable Development Goals |
| Description: |
Background: Investigation for the presence of asthma comorbidities is recommended by GINA as their presence can complicate asthma management. Objective: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes. Methods: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. Thirty comorbidities were identified and categorized a priori as either (1) potentially T2-related, (2) potentially oral corticosteroid (OCS)-related or (3) mimicking/aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex. Results: Of 11,821 patients, 69%, 67%, and 55% had ≥1 potentially T2-related, potentially OCS-related, or mimicking/aggravating comorbidities, respectively; 57% had ≥3 comorbidities, and 33% had comorbidities in all three categories. Patients with allergic rhinitis (AR), nasal polyposis (NP), and chronic rhinosinusitis (CRS) experienced 1.12- (p=0.003), 1.16- (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Annals of Allergy, Asthma & Immunology Vol. 132, Issue 1, p. 42-53; http://hdl.handle.net/1959.13/1499013; uon:54592 |
| Availability: |
http://hdl.handle.net/1959.13/1499013 |
| Rights: |
© 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. This article is available under the Creative Commons CC-BY-NC-ND license (https://creativecommons.org/licenses/) and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. |
| Accession Number: |
edsbas.CC2DDE0B |
| Database: |
BASE |