| Title: |
Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes |
| Authors: |
Pers, Tune H.; Timshel, Pascal; Ripke, Stephan; Lent, Samantha; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Sullivan, Patrick F.; O'Donovan, Michael C.; Franke, Lude; Hirschhorn, Joel N. |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2016 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
ASSOCIATION STUDIES ARTICLES |
| Description: |
Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach, we show that genes in associated loci: (1) are highly expressed in cortical brain areas; (2) are enriched for ion channel pathways (false discovery rates |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://hmg.oxfordjournals.org/cgi/content/short/25/6/1247; http://dx.doi.org/10.1093/hmg/ddw007 |
| DOI: |
10.1093/hmg/ddw007 |
| Availability: |
http://hmg.oxfordjournals.org/cgi/content/short/25/6/1247; https://doi.org/10.1093/hmg/ddw007 |
| Rights: |
Copyright (C) 2016, Oxford University Press |
| Accession Number: |
edsbas.CC569D7 |
| Database: |
BASE |