| Title: |
PARP inhibitors: new tools to protect from inflammation. |
| Authors: |
Giansanti V; Donà F; Tillhon M; Scovassi AI. |
| Source: |
Biochemical pharmacology 80 (2010): 1869–1877. doi:10.1016/j.bcp.2010.04.022 ; info:cnr-pdr/source/autori:Giansanti V, Donà F, Tillhon M, Scovassi AI./titolo:PARP inhibitors: new tools to protect from inflammation./doi:10.1016j.bcp.2010.04.022/rivista:Biochemical pharmacology/anno:2010/pagina_da:1869/pagina_a:1877/intervallo_pagine:1869–1877/volume:80 |
| Publisher Information: |
Pergamon Press,, New York , Regno Unito |
| Publication Year: |
2010 |
| Collection: |
PUMAlab (ISTI CNR - Consiglio Nazionale delle Ricerche / National Research Council) |
| Subject Terms: |
Inflammation; Necrosis; NF-kB; PARP; ROS |
| Description: |
Poly(ADP-ribosylation) consists in the conversion of ss-NAD(+) into ADP-ribose, which is then bound to acceptor proteins and further used to form polymers of variable length and structure. The correct turnover of poly(ADP-ribose) is ensured by the concerted action of poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG) enzymes, which are responsible for polymer synthesis and degradation, respectively. Despite the positive role of poly(ADP-ribosylation) in sensing and repairing DNA damage, generated also by ROS, PARP over-activation could allow NAD depletion and consequent necrosis, thus leading to an inflammatory condition in many diseases. In this respect, inhibition of PARP enzymes could exert a protective role towards a number of pathological conditions; i.e. the combined treatment of tumors with PARP inhibitors/anticancer agents proved to have a beneficial effect in cancer therapy. Thus, pharmacological inactivation of poly(ADP-ribosylation) could represent a novel therapeutic strategy to limit cellular injury and to attenuate the inflammatory processes that characterize many disorders. Copyright © 2010. Published by Elsevier Inc. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:cnr-pdr/author/matricola:19184/SCOVASSI/ANNA; http://www.cnr.it/prodotto/i/27556; https://publications.cnr.it/doc/27556; https://dx.doi.org/10.1016/j.bcp.2010.04.022; info:doi:10.1016/j.bcp.2010.04.022; http://www.ncbi.nlm.nih.gov/pubmed/20417190 |
| DOI: |
10.1016/j.bcp.2010.04.022 |
| Availability: |
http://www.cnr.it/prodotto/i/27556; https://publications.cnr.it/doc/27556; https://doi.org/10.1016/j.bcp.2010.04.022; http://www.ncbi.nlm.nih.gov/pubmed/20417190 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.CC5D3C5A |
| Database: |
BASE |