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Selective Mono- and Diamination of 2,6-Dibromopyridine for the Synthesis of Diaminated Proligands

Title: Selective Mono- and Diamination of 2,6-Dibromopyridine for the Synthesis of Diaminated Proligands
Authors: Alexander S. Underwood; Mark A. Botrous; Nate T. Lobb; Emmett M. Neal; Charlotte A. Richter; Mathieu A. Sleiman; Adrian B. Frye; Matthew Roberts; Clifford W. Padgett; Gary L. Guillet
Publication Year: 1753
Collection: University of Sussex (US): Figshare
Subject Terms: Biochemistry; Cell Biology; Molecular Biology; Biotechnology; Ecology; Space Science; Environmental Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; 3
Description: Selective mono- or diaminations of 2,6-dibromopyridine were performed using microwave irradiation with water as solvent in 2–2.5 h. The only significant difference between the syntheses was the inclusion of K 2 CO 3 as base and CuI/DMPAO catalyst for the diaminations. The mono- and diaminations had approximately 7 and 2 g isolated yields, respectively. The monoaminated bromopyridines were attached to a TREN scaffolding molecule yielding novel ligands to support extended metal atom chain complexes.
Document Type: article in journal/newspaper
Language: unknown
DOI: 10.1021/acsomega.5c04396.s001
Availability: https://doi.org/10.1021/acsomega.5c04396.s001; https://figshare.com/articles/journal_contribution/Selective_Mono-_and_Diamination_of_2_6-Dibromopyridine_for_the_Synthesis_of_Diaminated_Proligands/29878756
Rights: CC BY-NC 4.0
Accession Number: edsbas.CC692E28
Database: BASE