| Title: |
The Yeast Motor Protein, Kar3p, Is Essential for Meiosis I |
| Authors: |
Bascom-Slack, Carol A.; Dawson, Dean S. |
| Source: |
The Journal of Cell Biology ; volume 139, issue 2, page 459-467 ; ISSN 0021-9525 1540-8140 |
| Publisher Information: |
Rockefeller University Press |
| Publication Year: |
1997 |
| Description: |
The recognition and alignment of homologous chromosomes early in meiosis is essential for their subsequent segregation at anaphase I; however, the mechanism by which this occurs is unknown. We demonstrate here that, in the absence of the molecular motor, Kar3p, meiotic cells are blocked with prophase monopolar microtubule arrays and incomplete synaptonemal complex (SC) formation. kar3 mutants exhibit very low levels of heteroallelic recombination. kar3 mutants do produce double-strand breaks that act as initiation sites for meiotic recombination in yeast, but at levels severalfold reduced from wild-type. These data are consistent with a meiotic role for Kar3p in the events that culminate in synapsis of homologues. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1083/jcb.139.2.459 |
| Availability: |
https://doi.org/10.1083/jcb.139.2.459; https://rupress.org/jcb/article-pdf/139/2/459/1845600/14528.pdf |
| Accession Number: |
edsbas.CCA25C6A |
| Database: |
BASE |