| Title: |
Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms |
| Authors: |
Santiago Elizondo-Benedetto, MD; Sergio Sastriques-Dunlop, MD; Lisa Detering, MS; Batool Arif, MS; Gyu Seong Heo, PhD; Deborah Sultan, BS; Hannah Luehmann, MS; Xiaohui Zhang, PhD; Xuefeng Gao, PhD; Andrea Bredemeyer, PhD; Mohamed S. Zaghloul, MD; Kitty Harrison, BS; Dakkota Thies, BS; Laura McDonald, BS; Christophe Combadière, PhD; Chieh-Yu Lin, MD, PhD; Yeona Kang, PhD; Jie Zheng, PhD; Joseph Ippolito, MD, PhD; Richard Laforest, PhD; Kory Lavine, MD, PhD; Robert J. Gropler, MD; Sean J. English, MD; Mohamed A. Zayed, MD, PhD; Yongjian Liu, PhD |
| Source: |
JACC: Basic to Translational Science, Vol 10, Iss 7, Pp 101250- (2025) |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
abdominal aortic aneurysm; CCR2; inflammation; theranostic; translation; Diseases of the circulatory (Cardiovascular) system; RC666-701 |
| Description: |
Summary: Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a high mortality upon rupture. There is no diagnosis to predict the rupture nor effective medical therapies to prevent rupture. Here we demonstrate that the C-C chemokine receptor type 2 (CCR2) is a theranostic biomarker for AAA. In rat AAA models, we determined the potential of a CCR2-targeted positron emission tomography radiotracer [64Cu]Cu-DOTA-ECL1i predicting AAA rupture. Using a CCR2 inhibitor, we observed the effective prevention of rupture in AAA rat models. In humans, CCR2 positron emission tomography showed intense radiotracer uptake along the AAA wall in patients while little signal was observed in healthy volunteers. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2452302X25000671; https://doaj.org/toc/2452-302X; https://doaj.org/article/36ff84107dd74ec18dfca5c4c5900049 |
| DOI: |
10.1016/j.jacbts.2025.02.010 |
| Availability: |
https://doi.org/10.1016/j.jacbts.2025.02.010; https://doaj.org/article/36ff84107dd74ec18dfca5c4c5900049 |
| Accession Number: |
edsbas.CD14F5 |
| Database: |
BASE |