| Title: |
The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals |
| Authors: |
Zhang, Xiao-Ai; Guo, Chen-Tao; Lu, Qing-Bin; Hu, Jian-Gong; Cui, Ning; Yang, Zhen-Dong; Peng, Wei; Liu, Rong; Hu, Chun-Yan; Qin, Shu-Li; Wang, Xian-Jun; Ding, Shu-Jun; Huang, Dou-Dou; Liu, Wei; Cao, Wu-Chun |
| Contributors: |
Liu, W; Cao, WC (reprint author), Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China.; Liu, W (reprint author), Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China.; Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China.; Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China.; Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China.; Peoples Liberat Army, Hosp 154, Xinyang 464000, Peoples R China.; Shangcheng Peoples Hosp, Xinyang 464000, Peoples R China.; Shandong Prov Ctr Dis Control & Prevent, Jinan 250001, Peoples R China. |
| Source: |
PubMed ; SCI |
| Publisher Information: |
ONCOTARGET |
| Publication Year: |
2016 |
| Collection: |
Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| Subject Terms: |
severe fever with thrombocytopenia syndrome; polymorphism; susceptibility; PDGF-B; cytokines; SYNDROME VIRUS; HEMORRHAGIC-FEVER; BUNYAVIRUS; PATHOGENESIS; INFECTION |
| Description: |
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV). We hypothesize that host genetic variations may contribute to susceptibility to SFTS. Results: Compared with the rs1800818 AA genotype, AG + GG genotypes were significantly associated with increased susceptibility to SFTS (odds ratio, 1.66, 95% confidence interval = 1.28-2.16; P < 0.001). By using the ELISA assay, we observed that PDGF-BB concentration was significantly reduced in acute phase of patients than in the controls (P < 0.001) and recovered patients at 6 month (P = 0.007) and 12 month (P = 0.003). A persistently reduced PDGF-BB was also revealed from the SFTSV-infected C57BL/6J mice (P < 0.001). The rs1800818 G allele was associated with decreased serum PDGF-BB levels in SFTS patients at their early infection (P = 0.015). In accordance, the relative mRNA levels of the at-risk G allele of 1800818 were lower than those of the A allele in heterozygous cell from acute phase of SFTS patients. PDGF-B rs1800818 conferred no susceptibility to severe or fatal outcome in SFTS patients. Materials and Methods: An initially small-scale case-control association study guided the selection of platelet derived growth factor-B (PDGF-B) rs1800818 in 1020 SFTS patients and 1353 controls. Functional analyses were conducted to verify the biological significance of rs1800818 polymorphism. Conclusions: Our findings suggest that the PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to SFTS. ; National Natural Science Foundation [81222037, 81473023]; China Mega-Project on Infectious Disease Prevention [2013ZX10004202]; Special Fund for Quarantine-Scientific Research in the Public Interest [201310076] ; SCI(E) ; PubMed ; ARTICLE ; lwbime@163.com; caowc@bmi.ac.cn ; 22 ; 33340-33349 ; 7 |
| Document Type: |
journal/newspaper |
| Language: |
English |
| Relation: |
1389703; http://hdl.handle.net/20.500.11897/433854; WOS:000377748500137 |
| DOI: |
10.18632/oncotarget.9043 |
| Availability: |
https://hdl.handle.net/20.500.11897/433854; https://doi.org/10.18632/oncotarget.9043 |
| Accession Number: |
edsbas.CD6DF431 |
| Database: |
BASE |