| Title: |
ATF4 Signaling in HIV Infection: Viral Subversion of a Stress Response Transcription Factor |
| Authors: |
Corne, Adrien; Adolphe, Florine; Estaquier, Jérôme; Gaumer, Sébastien; Corsi, Jean-Marc |
| Contributors: |
Laboratoire de génétique et biologie cellulaire (LGBC); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ); Centre de recherche du CHU de Québec-Université Laval (CRCHUQ); CHU de Québec–Université Laval; Université Laval Québec (ULaval)-Université Laval Québec (ULaval); Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité) |
| Source: |
ISSN: 2079-7737 ; Biology ; https://uvsq.hal.science/hal-04419778 ; Biology, 2024, ⟨10.3390/biology13030146⟩. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2024 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
ISR; AIDS; immunity; mitochondria; ER stress; UPR; [SDV]Life Sciences [q-bio]; [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
| Description: |
International audience ; Cellular integrated stress response (ISR), the mitochondrial unfolded protein response (UPRmt), and IFN signaling are associated with viral infections. Activating transcription factor 4 (ATF4) plays a pivotal role in these pathways and controls the expression of many genes involved in redox processes, amino acid metabolism, protein misfolding, autophagy, and apoptosis. The precise role of ATF4 during viral infection is unclear and depends on cell hosts, viral agents, and models. Furthermore, ATF4 signaling can be hijacked by pathogens to favor viral infection and replication. In this review, we summarize the ATF4-mediated signaling pathways in response to viral infections, focusing on human immunodeficiency virus 1 (HIV-1). We examine the consequences of ATF4 activation for HIV-1 replication and reactivation. The role of ATF4 in autophagy and apoptosis is explored as in the context of HIV-1 infection programmed cell deaths contribute to the depletion of CD4 T cells. Furthermore, ATF4 can also participate in the establishment of innate and adaptive immunity that is essential for the host to control viral infections. We finally discuss the putative role of the ATF4 paralogue, named ATF5, in HIV-1 infection. This review underlines the role of ATF4 at the crossroads of multiple processes reflecting host–pathogen interactions. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/biology13030146 |
| Availability: |
https://uvsq.hal.science/hal-04419778; https://uvsq.hal.science/hal-04419778v2/document; https://uvsq.hal.science/hal-04419778v2/file/Biology%202024_ACorne.pdf; https://doi.org/10.3390/biology13030146 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.CD75B147 |
| Database: |
BASE |