| Title: |
Multicentre observational study on multisystem inflammatory syndrome related to COVID-19 in Argentina |
| Authors: |
Vainstein, Eduardo; Baleani, Silvia; Urrutia, Luis; Affranchino, Nicolás; Ackerman, Judith; Cazalas, Mariana; Goldsman, Alejandro; Sardella, Angela; Tolin, Ana Laura; Goldaracena, Pablo; Fabi, Mariana; Cosentino, Mariana; Magliola, Ricardo; Roggiero, Gustavo; Manso, Paula; Triguy, Jésica; Ballester, Celeste; Cervetto, Vanesa; Vaccarello, María; De Carli, Domingo Norberto; De Carli, Maria Estela; Ciotti, Ana Laura; Sicurello, María Irene; Rios Leiva, Cecilia; Villalba, Claudia; Hortas, María; Peña, Sonia; González, Gabriela; Zold, Camila Lidia; Murer, Mario Gustavo; Grippo, M.; Vázquez, H.; Morós, C.; Di Santo, M.; Villa, A.; Lazota, P.; Foti, M.; Napoli, N.; Katsikas, M. M.; Tonello, L.; Peña, J.; Etcheverry, M.; Iglesias, D.; Alcalde, A. L.; Bruera, M.J.; Bruzzo, V.; Giordano, P.; Pena Acero, F.; Netri Pelandi, G.; Pastaro, D.; Bleiz, J.; Rodríguez, M. F.; Laghezza, L.; Molina, M. B.; Patynok, N.; Chatelain, M. S.; Aguilar, M. J.; Gamboa, J.; Cervan, M.; Ruggeri, A.; Marinelli, I.; Checcacci, E.; Meregalli, C.; Damksy Barbosa, J.; Fernie, L.; Fernández, M. J.; Saenz Tejeira, M.M.; Cereigido, C.; Nunell, A.; Villar, D.; Mansilla, A. D.; Darduin, M. D. |
| Publisher Information: |
Wiley Blackwell Publishing, Inc |
| Collection: |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| Subject Terms: |
COVID-19; KAWASAKI DISEASE; KAWASAKI SHOCK SYNDROME; MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN; PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME; https://purl.org/becyt/ford/3.2; https://purl.org/becyt/ford/3 |
| Description: |
Background: The impact of the pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in low- and middle-income countries remains poorly understood. Our aim was to understand the characteristics and outcomes of PIMS-TS in Argentina. Methods: This observational, prospective, and retrospective multicenter study enrolled patients younger than 18 years-old manifesting PIMS-TS, Kawasaki disease (KD) or Kawasaki shock syndrome (KSS) between March 2020 and May 2021. Patients were followed-up until hospital discharge or death (one case). The primary outcome was pediatric intensive care unit (PICU) admission. Multiple logistic regression was used to identify variables predicting PICU admission. Results: Eighty-one percent, 82%, and 14% of the 176 enrolled patients fulfilled the suspect case criteria for PIMS-TS, KD, and KSS, respectively. Temporal association with SARS-CoV-2 was confirmed in 85% of the patients and 38% were admitted to the PICU. The more common clinical manifestations were fever, abdominal pain, rash, and conjunctival injection. Lymphopenia was more common among PICU-admitted patients (87% vs. 51%, p < 0.0001), who also showed a lower platelet count and higher plasmatic levels of inflammatory and cardiac markers. Mitral valve insufficiency, left ventricular wall motion alterations, pericardial effusion, and coronary artery alterations were observed in 30%, 30%, 19.8%, and 18.6% of the patients, respectively. Days to initiation of treatment, rash, lymphopenia, and low platelet count were significant independent contributions to PICU admission. Conclusion: Rates of severe outcomes of PIMS-TS in the present study agreed with those observed in high-income countries. Together with other published studies, this work helps clinicians to better understand this novel clinical entity. ; Fil: Vainstein, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina ; Fil: Baleani, Silvia. Gobierno de la Ciudad de Buenos Aires. Hospital ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/11336/203539; CONICET Digital; CONICET |
| Availability: |
https://hdl.handle.net/11336/203539 |
| Rights: |
info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| Accession Number: |
edsbas.CD8F7859 |
| Database: |
BASE |