| Title: |
Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma |
| Authors: |
Rodriguez, Sara; Celay, Jon; Goicoechea, Ibai; Jimenez, Cristina; Botta, Cirino; Garcia-Barchino, Maria-José; Garces, Juan-Jose; Larrayoz, Marta; Santos, Susana; Alignani, Diego; Vilas-Zornoza, Amaia; Perez, Cristina; Garate, Sonia; Sarvide, Sarai; Lopez, Aitziber; Reinhardt, Hans-Christian; Carrasco, Yolanda R; Sanchez-Garcia, Isidro; Larrayoz, Maria-Jose; Calasanz, Maria-Jose; Panizo, Carlos; Prosper, Felipe; Lamo-Espinosa, Jose-Maria; Motta, Marina; Tucci, Alessandra; Sacco, Antonio; Gentile, Massimo; Duarte, Sara; Vitoria, Helena; Geraldes, Catarina; Paiva, Artur; Puig, Noemi; Garcia-Sanz, Ramon; Roccaro, Aldo M; Fuerte, Gema; San Miguel, Jesus F; Martinez-Climent, Jose-Angel; Paiva, Bruno |
| Contributors: |
Rodriguez, Sara; Celay, Jon; Goicoechea, Ibai; Jimenez, Cristina; Botta, Cirino; Garcia-Barchino, Maria-José; Garces, Juan-Jose; Larrayoz, Marta; Santos, Susana; Alignani, Diego; Vilas-Zornoza, Amaia; Perez, Cristina; Garate, Sonia; Sarvide, Sarai; Lopez, Aitziber; Reinhardt, Hans-Christian; Carrasco, Yolanda R; Sanchez-Garcia, Isidro; Larrayoz, Maria-Jose; Calasanz, Maria-Jose; Panizo, Carlo; Prosper, Felipe; Lamo-Espinosa, Jose-Maria; Motta, Marina; Tucci, Alessandra; Sacco, Antonio; Gentile, Massimo; Duarte, Sara; Vitoria, Helena; Geraldes, Catarina; Paiva, Artur; Puig, Noemi; Garcia-Sanz, Ramon; Roccaro, Aldo M; Fuerte, Gema; San Miguel, Jesus F; Martinez-Climent, Jose-Angel; Paiva, Bruno |
| Publication Year: |
2022 |
| Collection: |
IRIS Università degli Studi di Palermo |
| Subject Terms: |
lymphoplasmacytic lymphoma; MYD88; B cell lymphoma; single cell |
| Description: |
Normal cell counterparts of solid and myeloid tumors accumulate mutations years before disease onset; whether this occurs in B lymphocytes before lymphoma remains uncertain. We sequenced multiple stages of the B lineage in elderly individuals and patients with lymphoplasmacytic lymphoma, a singular disease for studying lymphomagenesis because of the high prevalence of mutated MYD88. We observed similar accumulation of random mutations in B lineages from both cohorts and unexpectedly found MYD88L265P in normal precursor and mature B lymphocytes from patients with lymphoma. We uncovered genetic and transcriptional pathways driving malignant transformation and leveraged these to model lymphoplasmacytic lymphoma in mice, based on mutated MYD88 in B cell precursors and BCL2 overexpression. Thus, MYD88L265P is a preneoplastic event, which challenges the current understanding of lymphomagenesis and may have implications for early detection of B cell lymphomas. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35044826; info:eu-repo/semantics/altIdentifier/wos/WOS:000745886100027; volume:8; issue:3; firstpage:eabl4644; numberofpages:19; journal:SCIENCE ADVANCES; http://hdl.handle.net/10447/531181 |
| DOI: |
10.1126/sciadv.abl4644 |
| Availability: |
http://hdl.handle.net/10447/531181; https://doi.org/10.1126/sciadv.abl4644 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.CD959665 |
| Database: |
BASE |