| Title: |
Cognition and memory after Covid-19 in a large community sample |
| Authors: |
Hampshire, A; Azor, A; Atchison, C; Trender, W; Hellyer, PJ; Giunchiglia, V; Husain, M; Cooke, GS; Cooper, E; Lound, A; Donnelly, CA; Chadeau-Hyam, M; Ward, H; Elliott, P |
| Contributors: |
Imperial College Healthcare NHS Trust- BRC Funding; National Institute for Health Research; Medical Research Council (MRC); Department of Health; Abdul Latif Jameel Foundation; The Huo Family Foundation UK Limited; Health Data Research UK |
| Source: |
818 ; 806 |
| Publisher Information: |
Massachusetts Medical Society |
| Publication Year: |
2024 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
Adult; Humans; Cognition; Cognitive Dysfunction; COVID-19; Memory Disorders; SARS-CoV-2; Memory; England; Post-Acute COVID-19 Syndrome; 11 Medical and Health Sciences; General & Internal Medicine |
| Subject Geographic: |
United States |
| Description: |
BACKGROUND: Cognitive symptoms after coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are well-recognized. Whether objectively measurable cognitive deficits exist and how long they persist are unclear. METHODS: We invited 800,000 adults in a study in England to complete an online assessment of cognitive function. We estimated a global cognitive score across eight tasks. We hypothesized that participants with persistent symptoms (lasting ≥12 weeks) after infection onset would have objectively measurable global cognitive deficits and that impairments in executive functioning and memory would be observed in such participants, especially in those who reported recent poor memory or difficulty thinking or concentrating ("brain fog"). RESULTS: Of the 141,583 participants who started the online cognitive assessment, 112,964 completed it. In a multiple regression analysis, participants who had recovered from Covid-19 in whom symptoms had resolved in less than 4 weeks or at least 12 weeks had similar small deficits in global cognition as compared with those in the no-Covid-19 group, who had not been infected with SARS-CoV-2 or had unconfirmed infection (-0.23 SD [95% confidence interval {CI}, -0.33 to -0.13] and -0.24 SD [95% CI, -0.36 to -0.12], respectively); larger deficits as compared with the no-Covid-19 group were seen in participants with unresolved persistent symptoms (-0.42 SD; 95% CI, -0.53 to -0.31). Larger deficits were seen in participants who had SARS-CoV-2 infection during periods in which the original virus or the B.1.1.7 variant was predominant than in those infected with later variants (e.g., -0.17 SD for the B.1.1.7 variant vs. the B.1.1.529 variant; 95% CI, -0.20 to -0.13) and in participants who had been hospitalized than in those who had not been hospitalized (e.g., intensive care unit admission, -0.35 SD; 95% CI, -0.49 to -0.20). Results of the analyses were similar to those of propensity-score-matching analyses. In a comparison ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
New England Journal of Medicine; http://hdl.handle.net/10044/1/110909; RDF01; MR/R015600/1; n/a; COVID 19 RESPONSE; TF2022.05 (HDRUK2022.0117); None assigned |
| DOI: |
10.1056/NEJMoa2311330 |
| Availability: |
http://hdl.handle.net/10044/1/110909; https://doi.org/10.1056/NEJMoa2311330 |
| Rights: |
© 2024 Massachusetts Medical Society. All rights reserved. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy) ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.CD95E250 |
| Database: |
BASE |