| Title: |
Dataset related to the article 'Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency |
| Authors: |
Di Minno, A; Anesi, A; Chiesa, M; Cirillo, F; Colombo, G.I.; Orsini, R.C.; Capasso, F; Morisco, F; Fiorelli, S; Eligini, S; Cavalca, V; Tremoli, E; Porro, B; Di Minno, MND |
| Publisher Information: |
Zenodo |
| Publication Year: |
2020 |
| Collection: |
Zenodo |
| Description: |
This record contains raw data related to the article "Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency" ABSTRACT Background & Aims: Patients with cystathionine β-synthase deficiency (CBSD) exhibit high circulating levels of homocysteine and enhanced lipid peroxidation. Because enhanced homocysteine plays key roles in methylation reactions that govern lipid metabolism, we have characterized the plasma lipidome in CBSD patients. Methods and results: Using an ultra-high-performance liquid chromatography-electrospray ionization-quadrupole-time of flight- mass spectrometry method, plasma lipids were determined with an untargeted lipidomics approach in 11 CBSD patients and 11 matched healthy subjects (CTRL). Compared to CTRL, CBSD patients had a higher medium and long-chain polyunsaturated fatty acids (PUFA) content in phosphatidylethanolamine (PE) and lysophosphatidylethanolamine (LPE) species (p |
| Document Type: |
dataset |
| Language: |
unknown |
| Relation: |
https://zenodo.org/records/4068459; oai:zenodo.org:4068459; https://doi.org/10.5281/zenodo.4068459 |
| DOI: |
10.5281/zenodo.4068459 |
| Availability: |
https://doi.org/10.5281/zenodo.4068459; https://zenodo.org/records/4068459 |
| Accession Number: |
edsbas.CDAD1D74 |
| Database: |
BASE |