| Title: |
Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent-Onset Cognitive Impairment |
| Authors: |
Furia A.; Incensi A.; Delprete C.; Rizzo G.; Bonvegna S.; Piatti M.; Olivola E.; Ventruto F.; Vacchiano V.; Fileccia E.; Cilia R.; Modugno N.; Liguori R.; Donadio V. |
| Contributors: |
Furia, A.; Incensi, A.; Delprete, C.; Rizzo, G.; Bonvegna, S.; Piatti, M.; Olivola, E.; Ventruto, F.; Vacchiano, V.; Fileccia, E.; Cilia, R.; Modugno, N.; Liguori, R.; Donadio, V. |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
dementia; immunofluorescence; Lewy bodie; skin biopsy; synucleinopathy |
| Description: |
Immunofluorescence for phosphorylated alpha-synuclein in skin biopsy samples is an emerging biomarker in synucleinopathies comprising Dementia with Lewy bodies. In this pilot study, 19 patients with recent-onset (≤ 18 months) cognitive impairment underwent skin biopsy at baseline, with follow-up clinical re-evaluation. Five patients fulfilled the Dementia with Lewy bodies diagnosis, all of them positive for skin phosphorylated alpha-synuclein. The remaining 14 patients were all negative. Skin tissue immunofluorescence may represent a promising technique in identifying synuclein pathology in recent-onset cognitive decline: larger cohorts are needed to confirm our preliminary data. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40878868; info:eu-repo/semantics/altIdentifier/wos/WOS:001544228800001; volume:12; issue:9; firstpage:1919; lastpage:1925; numberofpages:7; journal:ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY; https://hdl.handle.net/11585/1030400 |
| DOI: |
10.1002/acn3.70133 |
| Availability: |
https://hdl.handle.net/11585/1030400; https://doi.org/10.1002/acn3.70133; https://onlinelibrary.wiley.com/doi/10.1002/acn3.70133 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND) ; license uri:iris.PUB17 |
| Accession Number: |
edsbas.CDD8EEF6 |
| Database: |
BASE |