| Title: |
Prevalence and predictors of vitamin D deficiency in young African children |
| Authors: |
Mogire, RM; Morovat, A; Muriuki, JM; Mentzer, AJ; Webb, EL; Kimita, W; Ndungu, FM; Macharia, AW; Cutland, CL; Sirima, SB; Diarra, A; Tiono, AB; Lule, SA; Madhi, SA; Sandhu, MS; Prentice, AM; Bejon, P; Pettifor, JM; Elliott, AM; Adeyemo, A; Williams, TN; Atkinson, SH |
| Publisher Information: |
BioMed Central |
| Publication Year: |
2021 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Background Children living in sub-Saharan Africa have a high burden of rickets and infectious diseases, conditions that are linked to vitamin D deficiency. However, data on the vitamin D status of young African children and its environmental and genetic predictors are limited. We aimed to examine the prevalence and predictors of vitamin D deficiency in young African children. Methods We measured 25-hydroxyvitamin D (25(OH)D) and typed the single nucleotide polymorphisms, rs4588 and rs7041, in the GC gene encoding the vitamin D binding protein (DBP) in 4509 children aged 0–8 years living in Kenya, Uganda, Burkina Faso, The Gambia and South Africa. We evaluated associations between vitamin D status and country, age, sex, season, anthropometric indices, inflammation, malaria and DBP haplotypes in regression analyses. Results Median age was 23.9 months (interquartile range [IQR] 12.3, 35.9). Prevalence of vitamin D deficiency using 25(OH)D cut-offs of Conclusions Approximately 0.6% and 7.8% of young African children were vitamin D deficient as defined by 25(OH)D levels |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s12916-021-01985-8 |
| Availability: |
https://doi.org/10.1186/s12916-021-01985-8; https://ora.ox.ac.uk/objects/uuid:658fa801-c32a-45b9-a9bd-804d5a6e0399 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.CE110891 |
| Database: |
BASE |