Additional file 4 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
| Title: | Additional file 4 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma |
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| Authors: | Benjamin Lin; Abigail K. Shelton; Erin Smithberger; Julia Ziebro; Kasey R. Skinner; Ryan E. Bash; Richard Kirkman; Allie Stamper; Madison Butler; Alex Flores; Steven P. Angus; Michael P. East; Timothy F. Cloughesy; David A. Nathanson; Michael E. Berens; Jann N. Sarkaria; Zev A. Binder; Donald M. O’Rourke; Timothy C. Howton; Brittany N. Lasseigne; Christopher D. Willey; Gary L. Johnson; Anita B. Hjelmeland; Frank B. Furnari; C. Ryan Miller |
| Publication Year: | 2025 |
| Collection: | Torrens University Australia: Figshare |
| Subject Terms: | Biochemistry; Medicine; Genetics; Pharmacology; Biotechnology; Marine Biology; Cancer; Hematology; Virology; Computational Biology; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; EGFR; Glioblastoma; Synthetic lethality; Kinome rewiring; Upfront combinatorial therapy |
| Description: | Supplementary Material 4: Fig. S3 Acquired resistance alters specific kinases. mRNA (AC, EG, IK) and protein (BD, FH, JL) levels of Pdgfr (A-D), Mapk3 (E-H), and Fgfr2 (I-L) in resistant models compared to the parental CEv3 model |
| Document Type: | still image |
| Language: | unknown |
| Relation: | https://figshare.com/articles/figure/Additional_file_4_of_Identifying_and_exploiting_combinatorial_synthetic_lethality_by_characterizing_adaptive_kinome_rewiring_of_EGFRvIII-driven_glioblastoma/29431978 |
| DOI: | 10.6084/m9.figshare.29431978.v1 |
| Availability: | https://doi.org/10.6084/m9.figshare.29431978.v1 |
| Rights: | CC BY |
| Accession Number: | edsbas.CE2340F5 |
| Database: | BASE |