| Title: |
Additive prognostic impact of the cerebrospinal fluid arginine/ornithine ratio to established clinical scores in aneurysmal subarachnoid hemorrhage |
| Authors: |
Weller, Johannes; Lampmann, Tim; Asoglu, Harun; Schneider, Matthias; Ehrentraut, Stefan Felix; Lehmann, Felix; Güresir, Erdem; Dorn, Franziska; Petzold, Gabor; Vatter, Hartmut; Zimmermann, Julian |
| Publisher Information: |
Frontiers |
| Publication Year: |
2023 |
| Collection: |
bonndoc - The Repository of the University of Bonn |
| Subject Terms: |
subarachnoid hemorrhage; outcome prognostication; ornithine; arginine; scores accuracy; cerebrospinal fluid; arginase 1; ddc:610 |
| Description: |
Cerebrospinal fluid (CSF) metabolites are increasingly recognized as prognostic factors in aneurysmal subarachnoid hemorrhage (SAH). The CSF arginine/ ornithine ratio (Arg/Orn) was shown to predict cerebral vasospasms and clinical outcome in SAH. The additive prognostic value of Arg/Orn over established prognostic scores has not been investigated. CSF Arg/Orn and the established prognostic scores SAH, FRESH, SAH-PDS, HAIR, Rosen–McDonald, Hunt and Hess, WFNS and modified Fisher scale were determined in a prospective cohort of patients with aneurysmal SAH. Logistic regression models to predict a favorable outcome, defined as a modified Rankin Scale score of 0–3 at 3 months follow- up, were constructed for each score, both with and without the addition of Arg/ Orn. The impact of Arg/Orn was assessed comparing logistic regression models containing the respective score with and without Arg/Orn with the likelihood ratio chi-squared test. CSF Arg/Orn and clinical scores were determined in 38 SAH patients. Arg/Orn was an independent predictor of clinical outcome when added to established prognostic scores (p < 0.05) with the exception of HAIR (p=0.078). All models were significantly improved if Arg/Orn was added as a covariable (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/20.500.11811/10801 |
| Availability: |
https://hdl.handle.net/20.500.11811/10801 |
| Rights: |
Namensnennung 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; openAccess |
| Accession Number: |
edsbas.CE478E5E |
| Database: |
BASE |