| Title: |
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants |
| Authors: |
Wang, A; Shen, J; Rodriguez, AA; Saunders, EJ; Chen, F; Janivara, R; Darst, BF; Sheng, X; Xu, Y; Chou, AJ; Benlloch, S; Dadaev, T; Brook, MN; Plym, A; Sahimi, A; Hoffman, TJ; Takahashi, A; Matsuda, K; Momozawa, Y; Fujita, M; Laisk, T; Figuerêdo, J; Muir, K; Ito, S; Liu, X; Project, Biobank Japan; Uchio, Y; Kubo, M; Kamatani, Y; Lophatananon, A; Wan, P; Andrews, C; Lori, A; Choudhury, PP; Schleutker, J; Tammela, TLJ; Sipeky, C; Auvinen, A; Giles, GG; Southey, MC; MacInnis, RJ; Cybulski, C; Wokolorczyk, D; Lubinski, J; Rentsch, CT; Cho, K; Mcmahon, BH; Neal, DE; Donovan, JL; Hamdy, FC; Travis, RC; Key, TJ; Hunter, DJ |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2024 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41588-023-01534-4 |
| Availability: |
https://doi.org/10.1038/s41588-023-01534-4; https://ora.ox.ac.uk/objects/uuid:25b697a7-8ab7-4a9a-ba02-3fffe6dbf5b2 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.CE5157D |
| Database: |
BASE |