| Title: |
P0323 Fat Mass as a Determinant of Extraintestinal Joint Manifestations in Crohn’s Disease: Evidence from a Body Composition-Based Stratification Analysis |
| Authors: |
Spagnuolo, R; Morano, D; Scarlata, G G M; Giudice, A; Ferro, Y; Marafioti, G; Carrabetta, F; Elisa, M; Suraci, E; Marasco, R; Imeneo, M; Noto, F R; Montalcini, T; Abenavoli, L; Pujia, A; Luzza, F |
| Source: |
Journal of Crohn’s and Colitis ; volume 20, issue Supplement_1 ; ISSN 1873-9946 1876-4479 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background Extraintestinal manifestations, particularly joint involvement, affect approximately 20–45% of patients with inflammatory bowel disease (IBD) and contribute substantially to overall disease burden1. Given the emerging role of body composition in modulating systemic inflammation2-3, this study investigated the association between Fat Mass (FM)% and extraintestinal joint manifestations (EJM). Methods A cross-sectional study included 81 Crohn’s Disease (CD, M/F=38/43; age 43±17 years; disease duration 12±11years); and 157 Ulcerative Colitis (UC; M/F=63/94; age 48±14 years; disease duration 14±10 years) patients who were evaluated at a tertiary referral center (March 2024-June 2025). All participants underwent body composition assessment and stratified by FM tertiles using bioelectrical impedance analysis (BIA). Chi-square, one-way ANOVA, and multivariate logistic regression analyses were used. Results Across FM% levels (tertiles) no significant differences emerged in clinical characteristics such as disease duration, extent, or phenotype neither in CD or UC patients (Table I and II). In CD but not in UC, FM% was associated with more frequent severe disease according to the Harvey–Bradshaw Index (p=0.001) (Table I). Forty-seven per cent (n = 38) CD and 39% (n = 61) UC patients had EJM. In particular, CD patients with the higher FM% exhibited a greater frequency of EJM (63%) compared to those in the mid (48%) and in the lowest range (29%) (Table I and Figure 1A). These findings were confirmed by the multivariate logistic regression model adjusted for disease duration and disease activity (OR 1.06, 95% CI 0.99-1.12; p=0.008). Conclusion In CD patients, higher FM% was associated with an increased prevalence of EJM. These findings suggest a possible link between excess adiposity and musculoskeletal involvement and a role for the body composition as a potential modifier of the extraintestinal disease burden. References: 1. Khrom, M., Long, M., & Dube, S., et al. (2024). Comprehensive association ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ecco-jcc/jjaf231.504 |
| Availability: |
https://doi.org/10.1093/ecco-jcc/jjaf231.504; https://academic.oup.com/ecco-jcc/article-pdf/20/Supplement_1/jjaf231.504/66494290/jjaf231.504.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.CEA1A53D |
| Database: |
BASE |