| Title: |
Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study |
| Authors: |
Lipnicki, Darren; Crawford, John, D.; Dutta, Rajib; Thalamuthu, Anbupalam; Kochan, Nicole; Andrews, Gavin; Lima-Costa, M. Fernanda; Castro-Costa, Erico; Brayne, Carol; Matthews, Fiona; Stephan, Blossom; Lipton, Richard; Katz, Mindy; Ritchie, Karen, A.; Scali, Jacqueline; Ancelin, Marie-Laure; Scarmeas, Nikolaos; Yannakoulia, Mary; Dardiotis, Efthimios; Lam, Linda; Wong, Candy; Fung, Ada; Guaita, Antonio; Vaccaro, Roberta; Davin, Annalisa; Kim, Ki, Woong; Han, Ji Won; Kim, Tae, Hui; Anstey, Kaarin, J; Cherbuin, Nicolas; Butterworth, Peter; Scazufca, Marcia; Kumagai, Shuzo; Chen, Sanmei; Narazaki, Kenji; Ng, Tze, Pin; Gao, Qi; Reppermund, Simone; Brodaty, Henry; Lobo, Antonio; Lopez-Anton, Raúl; Santabárbara, Javier; Sachdev, Perminder, S |
| Contributors: |
University of New South Wales Sydney (UNSW); Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ); Pasteur Network (Réseau International des Instituts Pasteur); University of Cambridge Cambridge, UK (CAM); Newcastle University Newcastle; Albert Einstein College of Medicine New York; Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC); Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); The University of Edinburgh; National and Kapodistrian University of Athens (NKUA); Columbia University New York; Harokopio University of Athens (HUA); The Chinese University of Hong Kong (CUHK); Tai Po Hospital; Seoul National University Seoul (SNU); Yonsei University; Australian National University (ANU); Universidade de São Paulo = University of São Paulo (USP); Kyushu University; Central South University Changsha; Fukuoka Institute of Technology (FIT); National University of Singapore (NUS); Centro de Investigación Biomédica en Red Salud Mental Madrid (CIBER-SAM); Universidad de Zaragoza = University of Zaragoza Saragossa University = Université de Saragosse; Funding for COSMIC comes from a National Health and Medical Research Council of Australia Program Grant (ID 1093083) and philanthropic contributions to The Dementia Momentum Fund (PSS). Funding for each of the contributing studies is as follows: The Brazilian Ministry of Health and Ministry of Science and Technology (MFLC, ECC); Major awards from the UK Medical Research Council and the Department of Health (CB, FEM, BCMS); National Institute on Health/National Institute on Aging grants (5P01 AG003949, 1R03 AG045474; RBL, MJK); Novartis (KR, JS, MLA); Alzheimer’s Association (IIRG-09-133014), ESPA-EU program Excellence Grant (ARISTEIA), which is co-funded by the European Social Fund and Greek National resources (189 10276/8/9/2011), and Ministry for Health and Social Solidarity, Greece (ΔΥ2β/οικ.51657/14.4.2009; NS, MY, ED); Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund, and an educational fund from Eisai (LCWL, CHYW, AWTF); Fondazione Golgi Cenci and Federazione Alzheimer Italia (AG, RV, AD); Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea Grant No. HI09C1379 (A092077); KWK, JWH, THK; National Health and Medical Research Council of Australia (Grants 973302, 179805, 157125 and 1002160; KJA, NC, PB); Wellcome Trust (grant code GR066133MA) and FAPESP-Brazil (grant code 2004/12694-8; MS); Health and Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare of Japan (H25-Ninchisho-Ippan-004) and a research grant from Sasaguri town, Fukuoka, Japan (SK, SC, KN); Research grants (No. 03/ 121/17/214 and No. 08/1/21/19/567) from the Biomedical Research Council, Agency for Science, Technology and Research (A_STAR) in Singapore (TPN, QG); National Health & Medical Research Council of Australia Program Grant (ID 350833; PSS, DML, NAK, JDC, AT, GA, SR, HB); Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain (Grants 94/ 1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, and G03/128) and Pfizer Foundation, Madrid (AL, RLA, JS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Source: |
ISSN: 1549-1277. |
| Publisher Information: |
CCSD; Public Library of Science |
| Publication Year: |
2017 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
Memory; Regional geography; Educational attainment; Language; Meta-analysis; Cognition; Cognitive impairment; Dementia; MESH: Age Factors; MESH: Aged; MESH: Humans; MESH: Longitudinal Studies; MESH: Male; MESH: Middle Aged; MESH: Risk Factors; MESH: Sex Factors; 80 and over; MESH: Apolipoproteins E/genetics; MESH: Cognitive Dysfunction/epidemiology; MESH: Cognitive Dysfunction/etiology; MESH: Cohort Studies; MESH: Educational Status; MESH: Female; MESH: Genotype; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health |
| Description: |
International audience ; BACKGROUND: The prevalence of dementia varies around the world, potentially contributed to by international differences in rates of age-related cognitive decline. Our primary goal was to investigate how rates of age-related decline in cognitive test performance varied among international cohort studies of cognitive aging. We also determined the extent to which sex, educational attainment, and apolipoprotein E ε4 allele (APOE*4) carrier status were associated with decline.METHODS AND FINDINGS: We harmonized longitudinal data for 14 cohorts from 12 countries (Australia, Brazil, France, Greece, Hong Kong, Italy, Japan, Singapore, Spain, South Korea, United Kingdom, United States), for a total of 42,170 individuals aged 54-105 y (42% male), including 3.3% with dementia at baseline. The studies began between 1989 and 2011, with all but three ongoing, and each had 2-16 assessment waves (median = 3) and a follow-up duration of 2-15 y. We analyzed standardized Mini-Mental State Examination (MMSE) and memory, processing speed, language, and executive functioning test scores using linear mixed models, adjusted for sex and education, and meta-analytic techniques. Performance on all cognitive measures declined with age, with the most rapid rate of change pooled across cohorts a moderate -0.26 standard deviations per decade (SD/decade) (95% confidence interval [CI] [-0.35, -0.16], p < 0.001) for processing speed. Rates of decline accelerated slightly with age, with executive functioning showing the largest additional rate of decline with every further decade of age (-0.07 SD/decade, 95% CI [-0.10, -0.03], p = 0.002). There was a considerable degree of heterogeneity in the associations across cohorts, including a slightly faster decline (p = 0.021) on the MMSE for Asians (-0.20 SD/decade, 95% CI [-0.28, -0.12], p < 0.001) than for whites (-0.09 SD/decade, 95% CI [-0.16, -0.02], p = 0.009). Males declined on the MMSE at a slightly slower rate than females (difference = 0.023 SD/decade, 95% CI ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28323832; PUBMED: 28323832; PUBMEDCENTRAL: PMC5360220 |
| DOI: |
10.1371/journal.pmed.1002261 |
| Availability: |
https://hal.umontpellier.fr/hal-02399392; https://hal.umontpellier.fr/hal-02399392v1/document; https://hal.umontpellier.fr/hal-02399392v1/file/Ancelin_13.pdf; https://doi.org/10.1371/journal.pmed.1002261 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.CEE886FD |
| Database: |
BASE |