| Title: |
Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study |
| Authors: |
Watts, Eleanor; Gonzales, Tomas; Strain, Tessa; Saint-Maurice, Pedro F.; Bishop, Tim; Chanock, Stephen J.; Johansson, Mattias; Keku, Temitope O.; Le Marchand, Loic; Moreno, Victor; Newcomb, Polly; Newton, Christina C.; Pai, Rish K.; Purdue, Mark P.; Ulrich, Cornelia M.; Smith-Byrne, Karl; Van Guelpen, Bethany; The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS; Eeles, Rosalind A.; Haiman, Christopher A.; Kote-Jarai, Zsofia; Schumacher, Fredrick R.; Benlloch, Sara; Olama, Ali Amin Al; Muir, Kenneth R.; Berndt, Sonja I.; Conti, David V.; Wiklund, Fredrik; Wang, Ying; Tangen, Catherine M.; Batra, Jyotsna; Clements, Judith A.; APCB BioResource (Australian Prostate Cancer BioResource); Grönberg, Henrik; Pashayan, Nora; Schleutker, Johanna; Albanes, Demetrius; Weinstein, Stephanie J.; Wolk, Alicja; West, Catharine M. L.; Mucci, Lorelei A.; Cancel-Tassin, Géraldine; Koutros, Stella; Sørensen, Karina Dalsgaard; Grindedal, Eli Marie; Neal, David E.; Hamdy, Freddie C.; Donovan, Jenny L.; Travis, Ruth C.; Hamilton, Robert J.; Ingles, Sue Ann; Rosenstein, Barry S.; Lu, Yong-Jie; Giles, Graham G.; MacInnis, Robert J.; Kibel, Adam S.; Vega, Ana; Kogevinas, Manolis; Penney, Kathryn L.; Park, Jong Y.; Stanford, Janet L.; Cybulski, Cezary; Nordestgaard, Børge G.; Nielsen, Sune F.; Brenner, Hermann; Maier, Christiane; Kim, Jeri; John, Esther M.; Teixeira, Manuel R.; Neuhausen, Susan L.; De Ruyck, Kim; Razack, Azad; Newcomb, Lisa F.; Lessel, Davor; Kaneva, Radka; Usmani, Nawaid; Claessens, Frank; Townsend, Paul A.; Castelao, Jose Esteban; Roobol, Monique J.; Menegaux, Florence; Khaw, Kay-Tee; Cannon-Albright, Lisa; Pandha, Hardev; Thibodeau, Stephen N.; Hunter, David J.; Kraft, Peter; Blot, William J.; Riboli, Elio; Day, Felix; Wijndaele, Katrien; Wareham, Nicholas; Matthews, Charles E.; Moore, Steven C.; Brage, Soren |
| Source: |
http://lobid.org/resources/99370671962606441#!, 130(1):114-124. |
| Publication Year: |
2023 |
| Collection: |
Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| Subject Terms: |
Cardiorespiratory Fitness [MeSH]; Colorectal Neoplasms/diagnosis [MeSH]; Humans [MeSH]; Breast Neoplasms/genetics [MeSH]; Risk Factors [MeSH]; Biological Specimen Banks [MeSH]; Breast Neoplasms/epidemiology [MeSH]; Colorectal Neoplasms/epidemiology [MeSH]; Article; Male [MeSH]; /692/499; UK Biobank [MeSH]; Colorectal Neoplasms/genetics [MeSH]; /692/4028/67/2324 |
| Description: |
Abstract Background The association of fitness with cancer risk is not clear. Methods We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, endometrial, breast, and prostate cancer in a subset of UK Biobank participants who completed a submaximal fitness test in 2009-12 (N = 72,572). We also investigated relationships using two-sample Mendelian randomisation (MR), odds ratios (ORs) were estimated using the inverse-variance weighted method. Results After a median of 11 years of follow-up, 4290 cancers of interest were diagnosed. A 3.5 ml O2⋅min−1⋅kg−1 total-body mass increase in fitness (equivalent to 1 metabolic equivalent of task (MET), approximately 0.5 standard deviation (SD)) was associated with lower risks of endometrial (HR = 0.81, 95% CI: 0.73–0.89), colorectal (0.94, 0.90–0.99), and breast cancer (0.96, 0.92–0.99). In MR analyses, a 0.5 SD increase in genetically predicted O2⋅min−1⋅kg−1 fat-free mass was associated with a lower risk of breast cancer (OR = 0.92, 95% CI: 0.86–0.98). After adjusting for adiposity, both the observational and genetic associations were attenuated. Discussion Higher fitness levels may reduce risks of endometrial, colorectal, and breast cancer, though relationships with adiposity are complex and may mediate these relationships. Increasing fitness, including via changes ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://repository.publisso.de/resource/frl:6508154; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10781786/ |
| DOI: |
10.1038/s41416-023-02489-3 |
| Availability: |
https://repository.publisso.de/resource/frl:6508154; https://doi.org/10.1038/s41416-023-02489-3; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10781786/ |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.CEF144C0 |
| Database: |
BASE |