| Title: |
High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohn’s Disease |
| Authors: |
Beaugerie, Laurent; Carrat, Fabrice; Nahon, Stéphane; Zeitoun, Jean-David; Sabaté, Jean-Marc; Peyrin-Biroulet, Laurent; Colombel, Jean-Frédéric; Allez, Matthieu; Fléjou, Jean-François; Kirchgesner, Julien; Svrcek, Magali; Cosnes, Jacques; Gendre, Jean-Pierre; Lémann, Marc; Hébuterne, Xavier; Cortot, Antoine; Bouhnik, Yoram; Laharie, David; Dupas, Jean Louis; Flourié, Bernard; Lerebours, Eric; Messing, Bernard; Cadiot, Guillaume; Marteau, Philippe; Soulé, Jean-Claude; Gornet, Jean-Marc; Veyrac, Michel; Duclos, Bernard; Beau, Philippe; Bourreille, Arnaud; Baumer, Philippe; Carbonnel, Franck; Heresbach, Denis; Metman, Etienne-Henry; Florent, Christian; Blain, Antoine; Faucheron, Jean-Luc; Bonaz, Bruno; Roblin, Xavier; Potier, Pascal; Boehm, Christian; Kurtz, Thierry; Lamouliatte, Hervé; Nion-Larmurier, Isabelle; Delchier, Jean-Charles; Chaussade, Stanislas; Weiss, Anne Marie; Cézard, Jean Pierre; Siproudhis, Laurent; Sondag, Daniel; Jian, Raymond; Souquet, Jean-Christophe; Bord, Pierre; Coffin, Benoit; D’almagne, Hélène; Delasalle, Patrick; Fournier, Régis; Cavicchi, Maryan; Souffran, Marc-Henry; Vandromme, Luc; Guedon, Claire; Seksik, Philippe; Michiels, Christophe; Renard, Pascal; Rogier, Patrice; Gouilloud, Sylvie; Rotenberg, André; Savoye, Guillaume; Thevenin, Alain; Mallet, Laurent; Brazier, Franck; Jean, Francois; Justum, Anne-Marie; Latrive, Jean-Paul; Gerbal, Jean-Luc; Pierrugues, Robert; Chardonnal, Gérard; Picon, Laurence; Reix, Nicole; D’aubigny, Nicolas Drouët; Uettwiller, Hervé; Mallet, Anne Courillon; Palacci, Alain; Bensaude, Raoul-Jacques; Bonniaud, Pierre; Empinet, Olivier; Nisard, Andrée; Rudelli, Alain; Tubiana, Bernard; Capelle, Philippe; Dabadie, Alain; Evard, Daniel; Julien, Pierre-Emile; Picon-Coste, Magali; Schneider, Stéphane; Goldfain, Denis; Bellanger, Jérôme; Blondelot, Jean-Pierre; Lamy, Philippe; Lemière, Sébastien; Mockly, Jean Francois; Pellat, Benoit; Gatineau-Sailliant, Gilles; Nalet, Bernard; Nancey, Stéphane; Kusielewicz, Daniel; Loison, Patrick; Popot, Jean-Michel; Merite, François; Roux, Jean-Pol; Afchain, Pauline; Blanquart, Alain; Heyries, Laurent; Reville, Marc; Viron, Dominique; Zerbib, Frank; Claviere, Christophe; Léostic, Didier; Pouderoux, Philippe; Moitry, Alain; Hagège, Hervé; Hugot, Jean-Pierre; Humeau, Benoit; Lederman, Emmanuel; Lescut, Dominique; Luneau, Fabrice; Mesnard, Bruno; Smadja, Lionel; Steinberg, Michel; Brun, Marc; Macaigne, Gilles; Marchal, Jean Luc; Ollivier, Stéphane; Ouvry, Dominique; Perche, Jean Paul; Rambaud, Serge; Benamouzig, Robert; Cazenave, Jean Louis; Coffin, Jean-Charles; Blazquez, Martine; Lagneau, Marion; Person, Bruno; Wittersheim, Christian; Napoleon, Bertrand; Cemachovic, Israël; Iglicki, Franck; Howaizi, Mehran; Leprince, Eric; Leurent, Bruno; Morin, Thierry; Darsouni, Riad; Attar, Alain; Baron, Philippe; Breton, Anne; Gillion, Jean Marie; Guemene, Jean-Marc; Jouffre, Claude; Moreau, Xavier; Claude, Pierre; Quinton, André; Abitbol, Vered; Brichard, Jean Michel; Desaint, Benoit; Bouygues, Martin; Chatrenet, Philippe; Salmeron, Marcelo; Silvie, Jean; Waldner, Bruno; Emery, Yves; Moraillon, Armand; Kunkel, Daniel; Dubois, Philippe; Faure, Patrick; l'Hirondel, Christian; Labérenne, Jean-Eric; Moreau, Pierre; Pereira, Adelino; Plihon, Genevieve; Wolff, Thierry; Ngo, Yann; Boruchowicz, Arnaud; Jost, Béatrice; Gotlib, Jean Pierre; Danne, Odile; Raoux, Philippe; Ramond-Bouhali, Marie-José; Baetz, Andre; Veyres, Bruno; Chapoutot, Christian; Le Dréau, Gérard; Filippi, Jérôme; Mudry, Jean; Kalt, Philippe; Minault, Sophie; Bounin, Pierre-André; Andréani, Tony; Charneau, Jacky; Reijasse, Didier; Bolze, Jean-Louis; Thaunat, Jean Luc; Le Couteulx, Christian; Maurage, Chantal; Bader, Robert; Codjovi, Philippe; Migairou, Jean-Luc; Morali, Alain; Rey, Philippe; Molard, Bruno Richard; Petit, Richard; Koch, Stéphane; Cassan, Philippe; Deschamps, Jean-Paul; Caby, Christine Meicler; Meurisse, Jean-Jacques; Prades, Philippe; Boulant, James; Diacono, Michel; Monsch, Jean-Marie; Dupuy, J-François; Bellaiche, Guy; Guegan, Martine; Comte, Jean-Marc; Cayla, Jean-Michel; Le Tallec, Francois; Meurisse, Franck; Desurmont, Philippe; Roget, Laurent; Bouyssou, Philippe; Le Gall, Bruno; Bloch, Francis; Larvol, Loic; Jullien, Monique; Moreau, Jacques; Rebouissoux, Laurent; Decroix, Bruno; Dib, Nina; Dieterling, Paul; Lenormand, Frédéric; Lagier, Emmanuel; Fallourd, Philippe; Charpin, Serge; Bertrand, Hugues; Bommelaer, Gilles; Battistelli, Daniel; Delon, Bernard; Dentant, Lionel; Dorval, Etienne; Dumortier, Jérôme; Gaye-Bareyt, Eric; Gerosa, Yves; Guez, Chantal; Mornet, Martine; Benfredj, Paul; Piperaud, René; Stremsdoerfer, Noel; Verdier, Eric; Grinholtz, Alain; Barjonet, Georges; See, Antoine; Arotçarena, Ramuntxo; Baudet, Anne; Broyer, Joel; Charachon, Antoine; Blondon, Hugues; Mouton, Pascal; Claudez, Hubert; Labat-Labourdette, Jacques; Haëm, Jacques; Estable, Patrick; Levy, Patrick; Rosenbaum, Alain; Balavoine, Yvon; Blanchi, Alain; Coutarel, Pierre; Delaperriere, Nadege; Dervichian, Michel; Marois, Francis; Seroka, Jacques; Michaud, Laurent; Leroy, Olivier; Meyran, Emmanuel; Poilroux, Bernard; Tensaouti, Abdallah; Paupard, Thierry; Agard, Dominique; Beaulieu, Sandrine; Benfiguig, Kader; Capony, Patrice; Cottereau, Jean; Desreumaux, Pierre; Dramard, Jean-Michel; Duché, Mathieu; Mamou, Patrick; Etienney, Isabelle; d'Abrigeon, Gilles; Godeberge, Béatrice; Tucat, Gilbert; Puech, Jean; Roger, Jean; Lapalus, Marie-George; Bauret, Paul; Houcke, Philippe; Pornin, Béatrice; Champigneulle, Bruno; Cuissard, Laurent; David, Xavier-Richard; Lombard, Frédéric; Granveau, Antoine; Hamon, Jean-François; Ink, Olivier; Blondel, Fabienne; Namias, Alain; Pillon, Didier; Reignier, Antoine; Tordjman, Gilles; Christidis, Christos; Zirabe, Simon; Audebert, Michel; Bion, Eric; Bourgeaux, Claude; Poupardin, Cécile; Deplaix, Philippe; Fratini, Gérard; Garnier, Thierry; Desseaux, Gerard; Magois, Hervé; Lochum, Sylvain; Vergier, Jean-Francois; Texereau, Patrick; Rat, Christel; Uzzan, Francoise; Vidal, Alain; Vinante, Nadia; Watrin, Bernard; Wurtz-Huckert, Cécile; Barre, Bruno; Ferbus, Dominique Chaslin; Contou, Jean-François; Coupier, Dominique; David, Benoit; Gargot, Dany; Huc, Denis; Barraya, Remy; Faroux, Roger; Fourgeaud, Jean-Luc; Grimprel, Hubert; Auroux, Jean; Rey, Jean-François; Arnoux, Jean Pierre; Lentini, Franck; Tardy, Ludovic; Mouterde, Olivier; Spyckerelle, Claire; Vacherot, Bruno; Weissman, Alain; Alpérine, Michel; Le Sidaner, Anne; Bonnet-Eymard, Pierre-Olivier; Colson, Jean Louis; Pellet, Daniel; Deltombe, Bernard; Edouard, André; Maechel, Henri; Jaillet, Jean-Claude; Genes, Julien; Leveque, Anne-Marie; Lucidarme, Damien; Maignan, Philippe; Gehrke, Nathalie Mallier; Sanchez, Jérôme; Tusseau, Frank; Casteur, Alban; Bottlaender, Jacques; Constantini, Denis; Coton, Thierry; Even, Philippe; Druart, Francois; Riot, François; Gauchet, Jean-Michel; Hecquet, Geneviève; Henry, Gerard; Hochain, Patrick; Arpurt, Jean Pierre; Medini, Abdelkrim; Dartois-Hoguin, Michele; Moindrot, Henri; Emery, Philippe; Periac, Pierre; Prunier, Annie; Renkes, Pascal; Tawil-Longreen, Christine; Vincent, Edmond; Vitte, René-Louis; Loeb, Christian; Carwana, Alain; Barbereau, Didier; Bohon, Philippe; Corrieri-Baizeau, Céline; Sahy, Daniel; Derreveaux, Philippe; David, Dominique; Desbazeille, François; Fontenelle, Patrick; Slama, Jean Luc; Le Mercier, Yvon; Certin, Michel; Reig, Jean Jacques; Rosa, Isabelle; Helbert, Thierry; Tounian, Patrick; Turner, Luc; Perot, Valéry; Aillet, Luc; Pauwels, Arnaud; Barré, Philippe; Nury, Bernard; Cazalbou, Claude; Devulder, Franck; Durget, Alain; Dubroca, Jeanne; Gaudy, Daniele; Greff, Michel; Jacques, Christian; Lafarge, Jocelyne; Kezachian, Gilles; Le Gall, Ronan; Pariente, Alex; Pinault, Tiphaine; Bismuth, Michaël; Boyer-Darrigrand, Nathalie; Bretagnolle, Philippe; Carpentier, Stephane; Cholet, Franck; Theodore, Christian; Combes, Rémi; Combet, Francois; Delanoe, Christophe; de Montigny, Stéphanie; Soudan, Denis; Fourdan, Olivier; Minier, Gilles; Languepin, Jeanne; Roche, Jean; Ginies, Jean-Louis; Nouel, Olivier; Petitgars, Philippe; Robin, Edith; Hamm, Romain; Roques, Jean François; Roussin-Bretagne, Sylvie; Sénéjoux, Agnès; Muron, Sophie; Bardoux, Nicolas; Berthelemy, Philippe; Madonia, Patrick; Carles, Bertrand; Reynier, Catherine; Cuillerier, Emmanuel; Dadamessi, Innocenti; Danis, Jacques; Debenes, Bernard; Dubuc-Rey, Nathalie; Lesur, Gilles; Jouet, Pauline; Lenaerts, Catherine; Garret, Marc; Mineur, Alexandra; Chabry, Bernard; Pigot, Francois; Rossi, Valérie; Tennenbaum, Ruth; Salloum, Julien; Slaoui, Maurice Hakim; Mathieu, Stéphane; Papapietro, Valérie; Viola, Sheila; Bezet, Alexis; Altman, Claude; Audan, Alain; Calabet, Jean; Masliah, Claude; Fayemendy, Laurent; Duruy, Marc; Gauffeny, Benoit; Helie, Ludovic; Imani, Kamran; Janin-Manificat, Raoul; Galmiche, Jean-Paul; Kerlirzin, Anne; Bedenne, Laurent; Locher, Christophe; Michaudel, Gilles; Missonnier, Gilles; Rinaldi-Dovio, Michel; Rouillon, Jean-Michel; Ecuer, Stéphane; Patenotte, Arnaud; Bronstein, Jean Ariel; Baty, Vincent; Bougnol, Michel; Bourbon, Pierre; Cerbelaud, Philippe; Chavaillon, Annick; Boiffin, Franck; Dubern, Béatrice; de Laguierce, Isabelle Duval; Greco, Fernand; Bouhot, Florence; Godeberge, Philippe; Grandmaison, Brigitte; Gros, Pascal; Targues, Guy; Corallo, Jacques; Boutin, Jean; Guillan, Jacques; Barbieux, Jean Pierre; Lariviere, Isabelle Loury; Le Genissel, Henri; Leroi, Henri; Bellaiche, Marc; Elie-Legrand, Marie-Claire; Dapoigny, Michel; Denoyel, Philippe; Pienkowski, Patrice; Pouche, Philippe; Saurfelt, Marc Michel; Thorel, Jean Marie; Piche, Thierry; Travers, Bruno; Tuvignon, Patrick; Zalcberg, Marc; Boulay, Guy; Zamora, Christophe; Samama, Joelle; Ricotie, Etienne; de Fleury, Patrice; Maille, Francois; Mougenel, Jean Louis; Gonot, Olivier; Menat, Jean Philippe; Kaassis, Mehdi; Lang, Francoise; Abramowitz, Laurent; Ganne, Nathalie; Pecriaux, Olivier; Seyrig, Jacques-Arnaud; Sobhani, Iradj; Parmentier, Thierry; van Nieuwenhuyse, Antoine; Weber, Francois-Xavier; Glibert, André; Bineau, Catherine; Canet, Bernard; Collin, Catherine; Cordet, Frederic; Parlier, David David; Carre, Dominique; Peytier, Annie; Fein, Francine; Barouk, Jerome; Dewannieux, Jacques; Hartwig, Johannes; Jouve, Jean-Louis; Laplane, Bertrand; Lascar, Gilles; Legrand, Christophe; Le Marchand, Pierre; Liebaert, Marie Pierre; Terdiman-Pire, Michele; Abdelli, Naceur; Neveu, Dominique; de la Lande, Philippe; de Saint Louvent, Patrick; Pelatan, Cécile; Petit, Agnès; Richecoeur, Martial; Texier, Frederic; Cazals, Jean Brice; Tissot, Bertrand; Mourrut, Christian; Doubremelle, Marie; Foltz, Marc; Gautier-Jubé, Florence; Martin, Jacques; Khouri, Elie; Lons, Thierry; Carlier-Bandu, Martine; Monnin, Jean-Luc; Roche, Hervé; Willemin, Bernard; Houard, Xavier; Fatisse, Abdelaziz; Algard, Michèle; Arab, Kamel; Borel, Isabelle; Lagarrigue, Cécile; Chryssostalis, Ariane; Boutroux, Dominique; Dupuychaffray, Jean-Pierre; Khaddari, Saïd; Mion, François; Puy-Montbrun, Thierry; Girardet, Jean-Philippe; Gury, Bruno; Landau, Alain; Le Bihan, Monique; Nieuviarts, Sandrine; Ollivry, Jean; Le Bourgeois, Philippe; Piquet, Marie-Astrid; Escartin, Michel -Pierre; Systchenko, Remi; Venezia, Franck; Wantiez, Michel; Lesage, Xavier; Zrihen, Elie; Aygalenq, Philippe; Dieumegard, Barbara; Savarieau, Bernard; Bulois, Philippe; Cattan, Stéphane; Diez, Jean-Lucien; Fauchot, Olivier; Durous, Eric; Gazut, Valérie; Guilleminet, Christian; Bories, Jean-Marc; Le Floch, Isabelle Joly; Vove, Jean-Paul; Lelouch, Stéphane; Lévy, Philippe; Lhopital, François; Marcato, Norma; Mozer-Bernardeau, Marianne; Nousbaum, Jean-Baptiste; Cattan, Philippe; Plane, Alain; Raymond, Jean-Michel; Roseau, Gilles; Rozental, Gerald; Boustière, Christian; Bonny, Corinne; Cordier-Collet, Mariepierre; Courat, Laurent; Croguennec, Bernard; Tardy, Karine Delaunay-; Labarriere, Damien; Geagea, Edmond; Gottrand, Frédéric; Gelsi, Eve; Thiefin, Gerard; Wohlschies, Eric; Miguet, Mathieu; Ponsot, Philippe; Suzanne, Jean; Teste, Yves; Dupont Gossart, Anne-Claire; Baroni, Jean-Luc; Benchaa, Benabdallah; Blanc, Georges; Maroy, Bernard; Bonjean, Philippe; Brézault, Catherine; Bridoux-Henno, Laure; Chayette, Claude; Auby, Dominique; Fiorucci, Robert; Galindo, Georges; Hubert, Gilles; Bonneau, Gilles; Marinier, Evelyne; Pouteau, Michele; Alamdari, Afchine; Delbende, Bruno; Chamouard, Patrick; d'Abravanel, Pascale; Dall'Osto, Hélène; Hervé, Sophie; Lefebvre, Jean; Levoir, Damien; Lillo, Philippe; Rouch, Michel; Mathonnet, Muriel; de Lustrac, Mercédes; Ramond, François-Jean; Roupret, Bernard; Soupison, Alain |
| Contributors: |
CHU Saint-Antoine AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Groupe Hospitalier Intercommunal Le Raincy-Montfermeil; Service de gastroentérologie; Université Paris 13 (UP13)-Hôpital Avicenne AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Service d'Hépato-gastro-entérologie CHRU Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Icahn School of Medicine at Mount Sinai New York (MSSM); Hopital Saint-Louis AP-HP (AP-HP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Alloimmunité-Autoimmunité-Transplantation (A2T); IFR de Saint-Louis - Institut universitaire d'hématologie (IFR105 - IUH); Université Paris Diderot - Paris 7 (UPD7)-Hopital Saint-Louis AP-HP (AP-HP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hopital Saint-Louis AP-HP (AP-HP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Service de Gastroentérologie Hôpital Beaujon; Hôpital Beaujon AP-HP; Service d'Hépato-Gastro-Entérologie; Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux)-Hôpital Saint-André; CHU Amiens-Picardie; Service d'Hépatologie et de Gastroentérologie Lyon; Hospices Civils de Lyon (HCL); Service d'Hépato-Gastroentérologie CHU Rouen; Hôpital Charles Nicolle Rouen; CHU Rouen; Normandie Université (NU)-Normandie Université (NU)-CHU Rouen; Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU); Hôpital universitaire Robert Debré Reims (CHU Reims); Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg); Hôpitaux Universitaires de Strasbourg (HUS); Department of Gastroenterology; Hôpital Bicêtre GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-GHU AP-HP. Université Paris Saclay-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-GHU AP-HP. Université Paris Saclay; Institut Mutualiste de Montsouris (IMM); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA) |
| Source: |
ISSN: 1542-3565 ; Clinical Gastroenterology and Hepatology ; https://hal.sorbonne-universite.fr/hal-03709242 ; Clinical Gastroenterology and Hepatology, 2018, 16 (6), pp.892-899.e2. ⟨10.1016/j.cgh.2017.11.041⟩. |
| Publisher Information: |
CCSD; WB Saunders |
| Publication Year: |
2018 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
Carcinogenesis; Inflammation; HPV; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background & AimsLittle is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohn’s disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohn’s perianal disease followed up in the Cancers Et Surrisque Associé aux Maladies Inflammatoires Intestinales En France (CESAME) cohort.MethodsWe collected data from 19,486 patients with inflammatory bowel disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14.9% of participants had past or current anal and/or perianal Crohn’s disease. Subjects were followed up for a median time of 35 months (interquartile range, 29–40 mo). To identify risk factors for anal cancer in the total CESAME population, we performed a case-control study in which participants were matched for age and sex.ResultsAmong the total IBD population, 8 patients developed anal cancer and 14 patients developed rectal cancer. In the subgroup of 2911 patients with past or current anal and/or perianal Crohn’s lesions at cohort entry, 2 developed anal squamous-cell carcinoma, 3 developed perianal fistula–related adenocarcinoma, and 6 developed rectal cancer. The corresponding incidence rates were 0.26 per 1000 patient-years for anal squamous-cell carcinoma, 0.38 per 1000 patient-years for perianal fistula–related adenocarcinoma, and 0.77 per 1000 patient-years for rectal cancer. Among the 16,575 patients with ulcerative colitis or Crohn’s disease without anal or perianal lesions, the incidence rate of anal cancer was 0.08 per 1000 patient-years and of rectal cancer was 0.21 per 1000 patient-years. Among factors tested by univariate conditional regression (IBD subtype, disease duration, exposure to immune-suppressive therapy, presence of past or current anal and/or perianal lesions), the presence of past or current anal and/or perianal lesions at cohort entry was the only factor significantly associated with development of anal cancer (odds ratio, 11.2; 95% ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29199142; PUBMED: 29199142 |
| DOI: |
10.1016/j.cgh.2017.11.041 |
| Availability: |
https://hal.sorbonne-universite.fr/hal-03709242; https://hal.sorbonne-universite.fr/hal-03709242v1/document; https://hal.sorbonne-universite.fr/hal-03709242v1/file/Beaugerie%20et%20al.%20-%202018%20-%20High%20Risk%20of%20Anal%20and%20Rectal%20Cancer%20in%20Patients%20Wi.pdf; https://doi.org/10.1016/j.cgh.2017.11.041 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.CF27242B |
| Database: |
BASE |