Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Title:	Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
Authors:	Okada Y; Sim X; Go MJ; Wu JY; Gu D; Takeuchi F; Takahashi A; Maeda S; Tsunoda T; Chen P; Lim SC; Wong TY; Liu J; Young TL; Aung T; Seielstad M; Teo YY; Kim YJ; Lee JY; Han BG; Kang D; Chen CH; Tsai FJ; Chang LC; Fann SJ; Mei H; Rao DC; Hixson JE; Chen S; Katsuya T; Isono M; Ogihara T; Chambers JC; Zhang W; Kooner JS; KidneyGen Consortium; CKDGen Consortium; Albrecht E; GUGC consortium; Yamamoto K; Kubo M; Nakamura Y; Kamatani N; Kato N; He J; Chen YT; Cho YS; Tai ES; Tanaka T.; Lord GM; van der Harst P; Lawlor DA; Sehmi JS; Gale DP; Wass MN; Ahmadi KR; Bakker SJ; Beckmann J; Bilo HJ; Bochud M; Brown MJ; Caulfield MJ; Connell JM; Cook HT; Cotlarciuc I; Smith GD; de Silva R; Deng G; Devuyst O; Dikkeschei LD; Dimkovic N; Dockrell M; Dominiczak A; Ebrahim S; Eggermann T; Farrall M; Ferrucci L; Floege J; Forouhi NG; Gansevoort RT; Han X; Hedblad B; van der Heide JJ; Hepkema BG; Hernandez Fuentes M; Hypponen E; Johnson T; de Jong PE; Kleefstra N; Lagou V; Lapsley M; Li Y; Loos RJ; Luan J; Luttropp K; Maréchal C; Melander O; Munroe PB; Nordfors L; Parsa A; Peltonen L; Penninx BW; Perucha E; Pouta A; Prokopenko I; Roderick PJ; Ruokonen A; Samani NJ; Sanna S; Schalling M; Schlessinger D; Schlieper G; Seelen MA; Shuldiner AR; Sjögren M; Smit JH; Snieder H; Soranzo N; Spector TD; Stenvinkel P; Sternberg MJ; Swaminathan R; Tanaka T; Ubink Veltmaat LJ; Uda M; Vollenweider P; Wallace C; Waterworth D; Zerres K; Waeber G; Wareham NJ; Maxwell PH; McCarthy MI; Jarvelin MR; Mooser V; Abecasis GR; Lightstone L; Scott J; Navis G; Elliott P; Köttgen A; Pattaro C; Böger CA; Fuchsberger C; Olden M; Glazer NL; Gao X; Yang Q; Smith AV; O'Connell JR; Li M; Schmidt H; Isaacs A; Ketkar S; Hwang SJ; Johnson AD; Dehghan A; Teumer A; Paré G; Atkinson EJ; Zeller T; Lohman K; Cornelis MC; Probst Hensch NM; Kronenberg F; Tönjes A; Hayward C; Aspelund T; Eiriksdottir G; Launer LJ; Harris TB; Rampersaud E; Mitchell BD; Arking DE; Boerwinkle E; Struchalin M; Cavalieri M; Singleton A; Giallauria F; Metter J; de Boer IH; Haritunians T; Lumley T; Siscovick D; Psaty BM; Zillikens MC; Oostra BA; Feitosa M; Province M; de Andrade M; Turner ST; Schillert A; Ziegler A; Wild PS; Schnabel RB; Wilde S; Munzel TF; Leak TS; Illig T; Klopp N; Meisinger C; Wichmann HE; Koenig W; Zgaga L; Zemunik T; Kolcic I; Minelli C; Hu FB; Johansson Å; Igl W; Zaboli G; Wild SH; Wright AF; Campbell H; Ellinghaus D; Schreiber S; Aulchenko YS; Felix JF; Rivadeneira F; Uitterlinden AG; Hofman A; Imboden M; Nitsch D; Brandstätter A; Kollerits B; Kedenko L; Mägi R; Stumvoll M; Kovacs P; Boban M; Campbell S; Endlich K; Völzke H; Kroemer HK; Nauck M; Völker U; Polasek O; Vitart V; Badola S; Parker AN; Ridker PM; Kardia SL; Blankenberg S; Liu Y; Curhan GC; Franke A; Rochat T; Paulweber B; Wang W; Gudnason V; Coresh J; Schmidt R; Shlipak MG; van Duijn CM; Borecki I; Krämer BK; Rudan I; Gyllensten U; Wilson JF; Witteman JC; Pramstaller PP; Rettig R; Hastie N; Chasman DI; Kao WH; Heid IM; Fox CS; Krumsiek J; Hundertmark C; Pistis G; Ruggiero D; O'Seaghdha M; Haller T; Kutalik Z; Shi J; Middelberg PS; Gaffo AL; Pirastu N; Li G; Huffman J; Yengo L; Zhao JH; Demirkan A; Feitosa MF; Liu X; Lopez LM; Li X; Kleber ME; Hicks AA; Nolte IM; Johansson A; Murgia F; Peden JF; Steri M; Tenesa A; Salo P; Mangino M; Rose LM; Lehtimäki T; Woodward OM; Tin A; Müller C; Oldmeadow C; Putku M; Czamara D; Kraft P; Frogheri L; Thun GA; Grotevendt A; Gislason GK; McArdle P; Schallert M; Martin NG; Montgomery GW; Jacobs DR Jr; Liu K; D'Adamo P; Ulivi S; Rotter JI; Navaro P; Balkau B; Froguel P; Esko T; Salumets A; Khaw KT; Langenberg C; Kraja A; Zhang Q; Scott RJ; Holliday EG; Org E; Viigimaa M; Bandinelli S; Metter JE; Sorice R; Döring A; Lattka E; Strauch K; Theis F; Waldenberger M; Davies G; Gow AJ; Bruinenberg M; Stolk RP; Winkelmann BR; Boehm BO; Lucae S; Curhan G; Mudgal P; Plenge RM; Portas L; Persico I; Kirin M; Mateo Leach I; van Gilst WH; Goel A; Ongen H; von Eckardstein A; Cucca F; Nagaraja R; Piras MG; Schurmann C; Budde K; Ernst F; Farrington SM; Theodoratou E; Jula A; Perola M; Salomaa V; Shin SY; Sala C; Kähönen M; Viikari J; Hengstenberg C; Nelson CP; Meschia JF; Nalls MA; Sharma P; Singleton AB; Burnier M; Attia J; Laan M; Hillege HL; Kloiber S; Choi H; Pirastu M; Tore S; Whitfield JB; Fornage M; Gasparini P; Siscovick DS; Bouatia Naji N; Metspalu A; Borecki IB; Gambaro G; Deary IJ; Wolffenbuttel BH; März W; Watkins H; Schipf S; Dunlop MG; Ripatti S; Toniolo D; Raitakari O; Ciullo M; Caulfield M; Gieger C.; MALERBA, Giovanni; LUPO, Antonio; TRABETTI, Elisabetta
Contributors:	Okada, Y; Sim, X; Go, Mj; Wu, Jy; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, Sc; Wong, Ty; Liu, J; Young, Tl; Aung, T; Seielstad, M; Teo, Yy; Kim, Yj; Lee, Jy; Han, Bg; Kang, D; Chen, Ch; Tsai, Fj; Chang, Lc; Fann, Sj; Mei, H; Rao, Dc; Hixson, Je; Chen, S; Katsuya, T; Isono, M; Ogihara, T; Chambers, Jc; Zhang, W; Kooner, J; Kidneygen, Consortium; Ckdgen, Consortium; Albrecht, E; Gugc, Consortium; Yamamoto, K; Kubo, M; Nakamura, Y; Kamatani, N; Kato, N; He, J; Chen, Yt; Cho, Y; Tai, E; Tanaka, T.; Lord, Gm; van der Harst, P; Lawlor, Da; Sehmi, J; Gale, Dp; Wass, Mn; Ahmadi, Kr; Bakker, Sj; Beckmann, J; Bilo, Hj; Bochud, M; Brown, Mj; Caulfield, Mj; Connell, Jm; Cook, Ht; Cotlarciuc, I; Smith, Gd; de Silva, R; Deng, G; Devuyst, O; Dikkeschei, Ld; Dimkovic, N; Dockrell, M; Dominiczak, A; Ebrahim, S; Eggermann, T; Farrall, M; Ferrucci, L; Floege, J; Forouhi, Ng; Gansevoort, Rt; Han, X; Hedblad, B; van der Heide, Jj; Hepkema, Bg; Hernandez Fuentes, M; Hypponen, E; Johnson, T; de Jong, Pe; Kleefstra, N; Lagou, V; Lapsley, M; Li, Y; Loos, Rj; Luan, J; Luttropp, K; Maréchal, C; Melander, O; Munroe, Pb
Publication Year:	2012
Collection:	Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS)
Subject Terms:	genetic; kidney; meta-analysis
Description:	Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/22797727; info:eu-repo/semantics/altIdentifier/wos/WOS:000306854700016; volume:44; issue:8; firstpage:904; lastpage:909; numberofpages:6; journal:NATURE GENETICS; https://hdl.handle.net/11562/478562; http://dx.doi.org/10.1038/ng.2352
DOI:	10.1038/ng.2352
Availability:	https://hdl.handle.net/11562/478562; https://doi.org/10.1038/ng.2352
Accession Number:	edsbas.CF276D72
Database:	BASE