| Title: |
Conducting molybdenum sulfide/graphene oxide/polyvinyl alcohol nanocomposite hydrogel for repairing spinal cord injury |
| Authors: |
Chen, Lingling; Wang, Wanshun; Lin, Zefeng; Lu, Yao; Chen, Hu; Li, Binglin; Li, Zhan; Xia, Hong; Li, Lihua; Zhang, Tao |
| Contributors: |
Foundation for Innovative Research Groups of the National Natural Science Foundation of China; Illinois Program for Research in the Humanities, University of Illinois at Urbana-Champaign; Science and Technology Planning Project of Guangdong Province; Natural Science Foundation of Chongqing; Scientific Research and Technology Development Program of Guangxi; Guangdong Province Introduction of Innovative R&D Team; Intramural technology program of Southern Theater Command General Hospital; Guangdong Basic and Applied Basic Research Foundation; National Natural Science Foundation of China |
| Source: |
Journal of Nanobiotechnology ; volume 20, issue 1 ; ISSN 1477-3155 |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2022 |
| Description: |
A sort of composite hydrogel with good biocompatibility, suppleness, high conductivity, and anti-inflammatory activity based on polyvinyl alcohol (PVA) and molybdenum sulfide/graphene oxide (MoS 2 /GO) nanomaterial has been developed for spinal cord injury (SCI) restoration. The developed (MoS 2 /GO/PVA) hydrogel exhibits excellent mechanical properties, outstanding electronic conductivity, and inflammation attenuation activity. It can promote neural stem cells into neurons differentiation as well as inhibit the astrocytes development in vitro. In addition, the composite hydrogel shows a high anti-inflammatory effect. After implantation of the composite hydrogel in mice, it could activate the endogenous regeneration of the spinal cord and inhibit the activation of glial cells in the injured area, thus resulting in the recovery of locomotor function. Overall, our work provides a new sort of hydrogels for SCI reparation, which shows great promise for improving the dilemma in SCI therapy. Graphical Abstract |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s12951-022-01396-8 |
| DOI: |
10.1186/s12951-022-01396-8.pdf |
| DOI: |
10.1186/s12951-022-01396-8/fulltext.html |
| Availability: |
https://doi.org/10.1186/s12951-022-01396-8; https://link.springer.com/content/pdf/10.1186/s12951-022-01396-8.pdf; https://link.springer.com/article/10.1186/s12951-022-01396-8/fulltext.html |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.CF8510AB |
| Database: |
BASE |