| Title: |
Immune recovery-related patterns of post kala-azar dermal and ocular leishmaniasis in people living with HIV |
| Authors: |
Rousset, Stella; Zenou, Mathilde; Saunier, Aurélie; Varenne, Fanny; Soler, Vincent; Tournier, Emilie; Legrand, Léa; Lachaud, Laurence; Buffet, Pierre A; Berry, Antoine; Delobel, Pierre; Martin‐blondel, Guillaume |
| Contributors: |
Service Maladies infectieuses et tropicales CHU Toulouse; Pôle Inflammation, infection, immunologie et loco-moteur CHU Toulouse (Pôle I3LM Toulouse); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Centre Hospitalier de Périgueux (CHP); Service d'Ophtalmologie CHU Toulouse; Pôle Céphalique CHU Toulouse; Service Hématologie - IUCT-Oncopole CHU Toulouse; Pôle Biologie CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement - délégation Occitanie (IRD Occitanie ); Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD)-Université de Montpellier (UM); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)); Institut National de la Transfusion Sanguine Paris (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre / Abymes Guadeloupe -Université des Antilles (UA)-Université Paris Cité (UPCité); Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Service de Parasitologie et Mycologie CHU Toulouse; Institut Fédératif de Biologie (IFB); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie CHU Toulouse |
| Source: |
ISSN: 0269-9370. |
| Publisher Information: |
CCSD; Wolters Kluwer |
| Publication Year: |
2022 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
HIV; Post kala-azar dermal leishmaniasis; Visceral leishmaniasis; MESH: Europe; MESH: HIV Infections; MESH: Humans; MESH: Leishmaniasis; Cutaneous; Visceral; MESH: Recurrence; [SDV.IMM]Life Sciences [q-bio]/Immunology |
| Description: |
International audience ; Objective: Post kala-azar dermal leishmaniasis (PKDL) is a rare complication of visceral leishmaniasis. We aimed at reporting PKDL cases in people living with HIV (PLHIV) and compare their characteristics based on whether PKDL occurred in the context of immune recovery under antiretroviral therapy (ART) or not.Design: National survey and literature review.Methods: We called for observations in France in October 2020 and performed a literature review from PubMed (Medline) and Web of Science up to December 2020. Two groups of patients were defined based on whether PKDL occurred in the context of immune recovery under ART (group 1) or not (group 2), and compared. Results: Three PLHIV with PKDL identified in France in the last decade were described and added to 33 cases from the literature. Compared with group 2 (16/36, 44.4%), patients from group 1 (20/36, 55.6%) originated more frequently from Europe (12/20, 60% vs. 2/16, 12.5%; P = 0.0038), had higher median blood CD4 + cell counts (221/μl vs. 61/μl; P = 0.0005) and increase under ART (122/μl, interquartile range 73–243 vs. 33/μl, interquartile range 0–53; P = 0.0044), had less frequently concomitant visceral leishmaniasis (3/20, 15% vs. 8/12, 66.7%; P = 0.006), and a trend to more frequent ocular involvement (7/20, 35% vs. 1/16, 6.25%; P = 0.0531). Conclusion: In PLHIV, PKDL occurs after a cured episode of visceral leishmaniasis as part of an immune restoration disease under ART, or concomitant to a visceral leishmaniasis relapse in a context of AIDS. For the latter, the denomination ‘disseminated cutaneous lesions associated with visceral leishmaniasis’ seems more accurate than PKDL. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35848585; PUBMED: 35848585; WOS: 000861441200009 |
| DOI: |
10.1097/QAD.0000000000003336 |
| Availability: |
https://hal.science/hal-04228818; https://hal.science/hal-04228818v1/document; https://hal.science/hal-04228818v1/file/immune_recovery_related_patterns_of_post_kala_azar.9.pdf; https://doi.org/10.1097/QAD.0000000000003336 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.CF9CE84F |
| Database: |
BASE |