| Title: |
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| Authors: |
Bastard, P; Gervais, A; Taniguchi, M; Saare, L; Särekannu, K; Le Voyer, T; Philippot, Q; Rosain, J; Bizien, L; Asano, T; Garcia-Prat, M; Parra-Martínez, A; Migaud, M; Tsumura, M; Conti, F; Belot, A; Rivière, JG; Morio, T; Tanaka, J; Javouhey, E; Haerynck, F; Duvlis, S; Ozcelik, T; Keles, S; Tandjaoui-Lambiotte, Y; Escoda, S; Husain, M; Pan-Hammarström, Q; Hammarström, L; Ahlijah, G; Abi Haidar, A; Soudee, C; Arseguel, V; Abolhassani, H; Sahanic, S; Tancevski, I; Nukui, Y; Hayakawa, S; Chrousos, GP; Michos, A; Tatsi, E-B; Filippatos, F; Rodriguez-Palmero, A; Troya, J; Tipu, I; Meyts, I; Roussel, L; Ostrowski, SR; Schidlowski, L; Prando, C; Condino-Neto, A; Cheikh, N; Bousfiha, AA; El Bakkouri, J; COVID Clinicians; GEN-COVID Study Group; COVID Human Genetic Effort; Peterson, P; Pujol, A; Lévy, R; Quartier, P; Vinh, DC; Boisson, B; Béziat, V; Zhang, S-Y; Borghesi, A; Pession, A; Andreakos, E; Marr, N; Mentis, A-FA; Mogensen, TH; Rodríguez-Gallego, C; Soler-Palacin, P; Colobran, R; Tillmann, V; Neven, B; Trouillet-Assant, S; Brodin, P; Abel, L; Jouanguy, E; Zhang, Q; Martinón-Torres, F; Salas, A; Gómez-Carballa, A; Gonzalez-Granado, LI; Kisand, K; Okada, S; Puel, A; Cobat, A; Casanova, J-L |
| Publisher Information: |
Rockefeller University Press |
| Publication Year: |
2024 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-ω and/or IFN-α2. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0022-1007 |
| Relation: |
pii: 276477; https://hdl.handle.net/11343/345891 |
| Availability: |
https://hdl.handle.net/11343/345891 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.CFB45879 |
| Database: |
BASE |