| Title: |
Relationships Between Köhne Category/Baseline Tumor Load and Early Tumor Shrinkage, Depth of Response, and Outcomes in Metastatic Colorectal Cancer |
| Authors: |
Sartore Bianchi A.; Garcia-Alfonso P.; Geissler M.; Kohne C. -H.; Peeters M.; Price T.; Valladares-Ayerbes M.; Zhang Y.; Burdon P.; Taieb J.; Modest D. P. |
| Contributors: |
A. Sartore Bianchi; P. Garcia-Alfonso; M. Geissler; C.-. Kohne; M. Peeter; T. Price; M. Valladares-Ayerbe; Y. Zhang; P. Burdon; J. Taieb; D.P. Modest |
| Publisher Information: |
Elsevier Inc. |
| Publication Year: |
2021 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
mCRC; OS; Panitumumab; PFS; Risk; Volume; Settore MED/06 - Oncologia Medica |
| Description: |
Background: In metastatic colorectal cancer (mCRC), there are limited data on associations between early tumor shrinkage (ETS), depth of response (DpR), and patient characteristics. Methods: Data from patients with RAS wild-type mCRC who had participated in the PRIME (NCT00364013) and PEAK (NCT00819780) studies were analyzed retrospectively. ETS and DpR were assessed by baseline Köhne category/BRAF status (PRIME) and baseline tumor load (pooled PRIME and PEAK). Results: Analysis populations included 436 to 665 patients. Patients’ chances of achieving ETS of 30% or greater were 63.8%, 50.4%, and 41.9% in the low-, medium-, and high-risk Köhne categories, and 21.7% in those with BRAF mutations. Corresponding percentages for the highest DpR classification (71%-100%) were 47.7% (low risk), 23.6% (medium risk), 10.0% (high risk), and 4.2% (BRAF mutant). No clear relationship was observed between baseline tumor load and ETS or DpR. An ETS of 30% or greater and higher DpR values were associated with statistically significant prolongation of median progression-free survival and overall survival. Conclusion: Patients with mCRC categorized at baseline by the Köhne criteria as high risk or with BRAF mutations have lower chances of achieving an ETS of 30% or greater or a high DpR. Baseline tumor load was not predictive of ETS or DpR. Favorable ETS or DpR is associated with improved progression-free and overall survival. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34172397; info:eu-repo/semantics/altIdentifier/wos/WOS:000731861000012; journal:CLINICAL COLORECTAL CANCER; https://hdl.handle.net/2434/865793 |
| DOI: |
10.1016/j.clcc.2021.05.007 |
| Availability: |
https://hdl.handle.net/2434/865793; https://doi.org/10.1016/j.clcc.2021.05.007 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.CFBDEF5 |
| Database: |
BASE |