| Title: |
Ventriculitis characteristics and outcomes (VELCRO): an international retrospective cohort study |
| Authors: |
Luque Paz, David; Pollan, Beatriz Diaz; Boyer-Besseyre, Marielle; Djanikian, Flora; Munier, Anne-Lise; Cunha, Flávia; Escaut, Lelia; Martin-Blondel, Guillaume; Sarton, Benjamine; Jaquet, Pierre; Arrivé, François; Wolf, Rémi; Legros, Vincent; Willig, Mathieu; Resat Sipahi, Oguz; Flurin, Laure; Bianchi, Antoine; Balança, Baptiste; Díez-Vidal, Alejandro; Puel, Joshua; Soyer, Benjamin; Lino, Rita; Lévèque, Thibaut; Salomon, Alexis; Serris, Alexandra; Larcher, Romaric; Bruneel, Fabrice; Mongardon, Nicolas; Martinot, Martin; Mazeraud, Aurelien; Wolff, Michel; Sonneville, Romain; Valour, Florent; Tattevin, Pierre |
| Contributors: |
Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; ARN bactériens et médecine (BRM); Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC); Hospital La Paz Institute for Health Research Madrid, Spain (IdiPaz); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Hôpital Lapeyronie CHU Montpellier; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Hôpital Lariboisière-Fernand-Widal APHP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Hospital de São João Porto; Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Hôpital Delafontaine; Centre Hospitalier de Saint-Denis Ile-de-France; Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Hôpital universitaire Robert Debré Reims (CHU Reims); Vieillissement, Fragilité (VIEFRA - EA 3797); Université de Reims Champagne-Ardenne (URCA); Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon); Ege university Izmir, Turkey; AP-HP - Hôpital Bichat - Claude Bernard Paris; Assistance Publique - Hôpitaux de Marseille (APHM); Aix Marseille Université (AMU); Hospices Civils de Lyon (HCL); CHU Montpellier = Montpellier University Hospital; Université de Montpellier (UM); CHU Clermont-Ferrand; CHU Amiens-Picardie; Service des Maladies infectieuses et tropicales CHU Necker; Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre Hospitalier Universitaire de Nîmes (CHU Nîmes); Centre Hospitalier de Versailles André Mignot (CHV); Hôpital Henri Mondor; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Henri Mondor Créteil; Groupe Henri Mondor-Albert Chenevier-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Henri Mondor-Albert Chenevier-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12); Hôpitaux Civils de Colmar; Centre Hospitalier Sainte Anne Paris; Groupe hospitalier universitaire Paris psychiatrie & neurosciences Paris (GHU Paris Psychiatrie et Neurosciences); Perception et Mémoire / Perception and Memory; Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Centre International de Recherche en Infectiologie (CIRI); École normale supérieure de Lyon (ENS de Lyon); Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); None. We are very grateful to all persons who contributed to the study, and to institutions that supported this project, namely the French Society of Infectious Diseases (SPILF) and French Clinical Research Network of Infectious Diseases (RENARCI), the French Society of Anesthesiology and Intensive Care (SFAR) Research Network, and the ESCMID Study Group for Infections of the Brain (ESGIB).; ESGIB-SPILF-SFAR Research Network-VELCRO study group: Alexis Salomon, Paul Jaubert, Ivan Pelegrin, María Milagros Montero, Pierre Bailly, Thibaut Leveque, Martin Martinot, Nicolas Mongardon, Mathieu Willig, Rémi Wolf, Oguz Resat Sipahi, Gamze Şanlıdağ İşbilen, Florent Valour, Florian Contard, Baptiste Balança, Pierre Goffin, Marielle Boyer-Besseyre, Beatriz Díaz-Pollán, Alejandro Díez-Vidal, Fernando Fernández Hinojal, Antoine Bianchi, Flora Djanikian, Joshua Puel, Lélia Escaut, Anne Herbrecht, Pierre Etienne Leblanc, Nicolas Fortineau, Laure Flurin, Romain Sonneville, Sarah Benghanem, Anne-Lise Munier, Benjamin Soyer, Alexandra Serris, Clémentine De La Porte Des Vaux, Fanny Lanternier, Alexandra Beurton, Romaric Larcher, Flávia Cunha, Rita Lino, Lurdes Santos, François Arrivé, Vincent Legros, François Eugène, David Luque Paz, Pierre Tattevin, Matthieu Revest, Pierre-Jean Le Reste, Pierre Jaquet, Marco Seneghini, Werner Albrich, Mathilde Zenou, Baptiste Jean, Benjamine Sarton, Guillaume Reiter, Delphine Dghayem, Fabrice Bonneville, Guillaume Martin-Blondel, Vanessa Jean-Michel, Florian Reizine, Fabrice Bruneel |
| Source: |
ISSN: 0006-8950. |
| Publisher Information: |
CCSD; Oxford University Press |
| Publication Year: |
2025 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
ventriculitis; meningitis; drain-related ventriculitis; central nervous system infections; brain abscess; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Ventriculitis is a dreaded complication of central nervous system infections, which has been scarcely described in the literature. We aimed to present a contemporary picture of ventriculitis, describing its characteristics and outcomes across the spectrum of aetiologies that may lead to ventriculitis. VELCRO is an international retrospective multicentre cohort study conducted at 34 hospitals in six countries. Adult patients fulfilling clinical, microbiological and imaging criteria of ventriculitis between 2010 and 2021 were included. Survival analyses were performed using a multivariable Cox proportional hazards regression model to identify risk factors for 1-year all-cause mortality. Overall, 436 patients with ventriculitis were included: 274 (62.8%) males, median age 58 years [interquartile range 48-68], 68 (15.6%) had diabetes mellitus and 62 (14.2%) were immunocompromised. The most common neuroimaging features of ventriculitis were ependymal enhancement (n=310/436, 71.1%), intraventricular pus (n=286/436, 65.6%) and intraventricular septations (n=85/436, 19.5%). To describe the cohort, patients were divided into three groups: ventriculitis with brain abscess(es) (V-BA, n=181), community-acquired ventriculitis without brain abscess (CA-V, n=88), and healthcare-associated ventriculitis without brain abscess (HCA-V, n=167). Intensive care unit admission was required for 351 patients (80.5%) and the median hospital length of stay was 45 days [26-74]. One-year mortality rate was 33.7% (n=147/436), with a lower rate in patients with V-BA (n=50/181, 27.6%) than in patients with CA-V (n=30/88, 34.1%) and HCA-V (n=67/167, 40.1%). On multivariable analysis, the predictive factors for 1-year mortality were: age > 60 years, immunosuppression, diabetes mellitus, Glasgow Coma Scale score < 13 at presentation, infection involving Enterobacterales or fungi, acute hydrocephalus, cerebral ischemia and intraventricular septations. Staphylococcal ventriculitis was associated with a lower 1-year ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40392145; PUBMED: 40392145 |
| DOI: |
10.1093/brain/awaf178 |
| Availability: |
https://hal.science/hal-05107921; https://hal.science/hal-05107921v1/document; https://hal.science/hal-05107921v1/file/Luque%20Paz%20et%20al.%20-%202025%20-%20Ventriculitis%20characteristics%20and%20outcomes%20%28VELCRO%29%20an%20international%20retrospective%20cohort%20study.pdf; https://doi.org/10.1093/brain/awaf178 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.CFE2FFB1 |
| Database: |
BASE |