| Title: |
Analysis of shared heritability in common disorders of the brain |
| Authors: |
Anttila, Verneri; Sullivan, Brenda; Finucane, Hilary; Walters, Walter; Bras, Jose; Duncan, Laramie; Price, Valentina; Falcone, Guido; Gormley, Padhraig; Malik, Rainer; Patsopoulos, Pat; Ripke, Stephan; Wei, Wei; Yu, Dongmei; Lee, Phil, L; Turley, Patrick; Grenier-Boley, Benjamin; Chouraki, Vincent; Kamatani, Yoichiro; Berr, Claudine; Letenneur, Luc; Hannequin, Didier; Amouyel, Philip; Boland, Anne; Deleuze, Jean-François; Duron, Emmanuelle; Vardarajan, N.; Reitz, Chris; Goate, Alison; Huentelman, Matthew; Kamboh, M. Ilyas; Larson, Lars; Rogaeva, Ekaterina; St George-Hyslop, Peter; Hakonarson, Hakon; Kukull, Walter; Li, Lindsay; Li, Lisa; Thomas, Thomas; Demirci, F. Yesim; Head, Eli; Hulette, Chris; Jicha, Gregory; Kauwe, John; Kaye, Jeffrey; Leverenz, James; Levey, Allan; Li, Andrew; Pankratz, Vernon; Poon, Wayne; Quinn, Joseph; Saykin, Andrew; Lo, Lon; Smit, Amanda; So, Joshua; Stern, Robert; van Deerlin, Vivianna; Li, Linda; Harold, Denise; Russo, Giancarlo; Rubinsztein, David, C.; Bayer, Anthony; Tsolaki, Magda; Proitsi, Petra; Fox, Nick; Hampel, Harald; Owen, Michael; Sim, Simon; Passmore, Peter; Morgan, Kevin; Markus, Mark; Schott, Jonathan; Kauffmann, Martin; Lupton, Michel; Hoffmann, Per; Kornhuber, Johannes; Lawlor, Brian; Mcquillin, Andrew; Al-Chalabi, Ammar; Bis, Joshua; Ruiz, Agustin; Boada, Mercè; Seshadri, Sudha; Beiser, Alexa; Rice, Kenneth; van Der Lee, Sven; de Jager, Philip; Geschwind, Dan; Riemenschneider, Matthias; Riedel-Heller, Helle; Rotter, Jerome; Ran, Gerhard; Hyman, Bradley, T.; Cruchaga, Carlos; Alegret, Montserrat; Winsvold, Bendik; Palta, Priit; Farh, Kai-How; Cuenca-Leon, Ester; Furlotte, Nicholas; Kurth, Tobias; Li, Lannie; Terwindt, Gisela; Freilinger, Tobias; Ran, Carol; Scott, Scott; Borck, Guntram; Adams, Hieab H.H.; Lehtimaki, Terho; Wedenoja, Juho; Buring, Julie; Hrafnsdottir, Maria; Hottenga, Jan; Penninx, Brenda; Artto, Ville; Kaunisto, Mari; Vepsäläinen, Salli; Martin, Nicholas, M; Montgomery, Grant, W.; Kurki, Mitja; Hämäläinen, Eija; Huang, Hailiang; Huang, Jie; Sandor, Cynthia; Webb, Caleb; Müller-Myhsok, Bertram; Schreiber, Stefan; Salomaa, Veikko; Lo, Eli; Göbel, Hartmut; Macaya, Alfons; Pozo-Rosich, Pat; Kaprio, Jaakko; Metspalu, Andres; Kubisch, Chris; Ferrari, Michel; Belin, Andrea; van den Maagdenberg, Arn M.J.M.; Zwart, John; Boomsma, Dorret, I.; Eriksson, Nicholas; Olesen, Ole; Chasman, Dan; Nyholt, Dale; Anney, Richard; Avbersek, Andreja; Bau, Larry; Berkovic, Samuel, F.; Bradfield, Jonathan; Buono, Russell; Catarino, Claudia; Cossette, Patrick; de Jonghe, Peter; Depondt, Chantal; Dlugos, Dennis; French, Jacqueline; Hjalgrim, Helle; Jamnadas-Khoda, Jennifer; Kälviäinen, Reetta; Kunz, Wolfram; Lerche, Holger; Leu, Costin; Li, Dick; Lo, Warren; Lowenstein, Dan; Mccormack, Mark; Møller, Rikke; Molloy, Anne; Ng, Ping-Wing; Oliver, Oliver; Privitera, Michael; Radtke, Rodney; Ruppert, Ann-Kathrin; Schachter, Steve; Schankin, Chris; Scheffer, Ingrid, E.; Schoch, Susan; Sisodiya, Sanjay; Smit, Philip; Sperling, Michael; Striano, Pasquale; Surges, Rainer; Visscher, Frank; Whelan, Chris; Zara, Federico; Heinzen, Erin; Marson, Anthony; Becker, Felicitas; Stroink, Hans; Zimprich, Fritz; Gasser, Thomas; Gibbs, Raphael; Heutink, Peter; Martinez, Matias; Morris, Huw; Sharma, Manu; Ryten, Mina; Mok, Kin; Pulit, Sara; Bevan, Steve; Holliday, Eli; Attia, John; Battey, Thomas; Boncoraglio, Giorgio; Thijs, Vincent; Chen, Wei; Mitchell, Braxton; Rothwell, Peter, M; Sharma, Pankaj; Cath, Cathie; Vicente, Astrid, M.; Kourkoulis, Chris; Pera, Joana; Mir, Miriam; Boraska Perica, Vesna; Thornton, Laura; Huckins, Laura; William Rayner, N.; Cath, Cathryn; Gratacòs, Mònica; Rybakowski, Filip; Keski-Rahkonen, Anna; Raevuori, Anu; Hudson, James; Reichborn-Kjennerud, Ted; Monteleone, Palmiero; Karwautz, Andreas; Männik, Katrin; Baker, Jessica; O’toole, Julie; Trace, Sara; Davis, Oliver; Helder, Sietske; Ehrlich, Stefan; Herpertz-Dahlmann, Beate; Danner, Dan; van Elburg, Annemarie; Clementi, Maurizio; Forzan, Monica; Docampo, Eli; Li, Jolanta; Hauser, Joanna; Tortorella, Alfonso; Maj, Mario; Gonidakis, Fragiskos; Tziouvas, Konstantinos; Papezova, Hana; Yilmaz, Zeynep; Wagner, Gudrun; Wood, Sarah; Herms, Stefan; Julià, Antonio; Rabionet, Raquel; Dick, Dan; Ripatti, Samuli; Andreassen, Andreas; Espeseth, Thomas; Lundervold, Astri; Steen, Vidar; Pinto, Dalila; Scherer, Stephen, W.; Aschauer, Harald; Schosser, Alexandra; Alfredsson, Lars; Padyukov, Leonid; Halmi, Katherine; Mitchell, James, Brian Alexander; Strober, Michael; Bergen, Andrew; Kaye, Walter; Szatkiewicz, Jin Peng; Cormand, Bru; Ramos, Josep Antoni; Sánchez-Mora, Cristina; Ribasés, Marta; Miguel, Miguel; Hervás, Amaia; Arranz, Maria; Haavik, Jan; Zayats, Tetyana; Johansson, Stefan; Williams, Nigel; Elia, Eli; Dempfle, Astrid; Rothenberger, Aribert; Kuntsi, Jonna; Oades, Robert, D.; Banaschewski, Tobias; Franke, Barbara; Buitelaar, Jan; Arias Vasquez, Alejandro; Doyle, Alysa, E.; Reif, Andreas; Lesch, Peter; Freitag, Chris; Rivero, Olga; Palmason, Haukur; Romanos, Marcel; Langley, Kate; Rietschel, Marcella; Witt, Stephanie; So, Soeren; Børglum, Anders, D.; Waldman, Irwin; Wilmot, Beth; Molly, Nikolas; Bau, Claiton H.D.; Crosbie, Jennifer; Schachar, Russell; Loo, Sandra, K.; Mcgough, James, J.; Grevet, Eugenio; Medland, Sarah, M; Robinson, Robin; Weiss, Wei; Bacchelli, Elena; Bailey, Anthony, J.; Bal, Vanessa; Battaglia, Agatino; Betancur, Catalina; Bolton, Patrick, F.; Cantor, Rita, M.; So, Pat; Dawson, Gerald; de Rubeis, Silvia; Duque, Frederico; Green, Andrew; Klauck, Sabine, M.; Leboyer, Marion; Levitt, Pat; Maestrini, Elena; Mane, Shrikant, M.; De-Luca, Dan; Parr, Jeremy, R.; Regan, Regina; Reichenberg, Abraham; Sandin, Sven; Vorstman, Jacob; Wassink, Thomas, H.; Wijsman, Ellen, M.; Cook, Edwin, H.; Santangelo, Susan, L.; Delorme, Richard; Rogé, Bernadette; Magalhaes, Tiago, R.; Arking, Dan, E.; Schulze, Thomas; Thompson, Robert, C.; Strohmaier, Jana; Matthews, Matthew; Melle, Ingrid; Morris, Derek; Blackwood, Douglas; Mcintosh, Andrew; Bergen, Sarah, E.; Schall, Martin; Jamain, Stéphane; Maaser, Anna; Fischer, Sascha; Reinbold, Céline; Fullerton, Janice; Grigoroiu-Serbanescu, Maria; Guzman-Parra, José; Mayoral, Fermin; Schofield, Peter, R.; Cichon, Sven; Mühleisen, Thomas; Degenhardt, Franziska; Schumacher, Johannes; Bauer, Michael; Mitchell, Philip, B.; Gershon, Elliot, S.; Rice, John, P.; Potash, James, B.; Zandi, Peter, P.; Craddock, Nick; Ferrier, I. Nicol; Alda, Martin; Rouleau, Guy, A.; Turecki, Gustavo; Ophoff, Roel; Pato, Carlos, N.; Anjorin, Adebayo; Stahl, Eli; Leber, Mark; Czerski, Piotr, M.; Edenberg, Howard, J.; Cruceanu, Cristiana; Jones, Ian, R.; Posthuma, Dan; Andlauer, Till F.M.; Forstner, Andreas; Streit, Fabian; Baune, Bernhard, T.; Air, Tracy; Sinnamon, Grant; Wray, Naomi, R.; Macintyre, Donald, J.; Porteous, David; Homuth, Georg; Rivera, Margarita; Grove, Jakob; Middeldorp, Chris; Hickie, Ian; Pergadia, Michele; Mehta, Divya; Smit, Johannes; Jansen, Rick; de Geus, Eco; Dunn, Erin; Li, Qingqin; Nauck, Matthias; Schoevers, Robert; Beekman, Aartjan Tf; Knowles, James; Viktorin, Alexander; Arnold, Paul; Cath, Cathy; Bedoya-Berrio, Gabriel; Bienvenu, O. Joseph; Brentani, Helena; Burton, Chris; Camarena, Beatriz; Cappi, Carol; Cath, Dan; Cavallini, Maria; Cusi, Dan; Darrow, Sabrina; Denys, Damiaan; Derks, Eske; Dietrich, Andrea; Fernandez, Thomas; Figee, Martijn; Freimer, Nelson, B.; Gerber, Gloria; Grados, Marco; Greenberg, Erica; Hanna, Gregory; Hartmann, Andreas; Hirschtritt, Matthew; Hoekstra, Pieter; Huang, Alden; Huyser, Chaim; Illmann, Cornelia; Jenike, Michael; Kuperman, Samuel; Leventhal, Bennett, L.; Lochner, Chris; Lyon, Gholson; Macciardi, Fabio; Madruga-Garrido, Marcos; Malaty, Irene; Maras, Athanasios; Mcgrath, Lauren; Miguel, Eurípedes; Mir, Pablo; Nestadt, Gerald; Nicolini, Humberto; Okun, Michael, S.; Pakstis, Andrew; Paschou, Peristera; Piacentini, John; Pittenger, Chris; Plessen, Kerstin; Ramensky, Vasily; Ramos, Eliana; Reus, Victor; Richter, Margaret; Riddle, Mark; Robertson, Robert; Roessner, Veit; Rosário, Maria; Samuels, Jack; Sandor, Paul; Stein, Dan, J; Tsetsos, Fotis; van Nieuwerburgh, Filip; Weatherall, Sarah; Wendland, Jens; Wolanczyk, Tomasz; Worbe, Yulia; Zai, Gwyneth; Goes, Fernando, S.; Mclaughlin, Nicole; Nestadt, Paul; Grabe, Hans-Jörgen; Depienne, Christel; Konkashbaev, Anuar; Lanzagorta, Nuria; Valencia-Duarte, Ana; Bramon, Elvira; Buccola, Nancy, G.; Cahn, Wiepke; Murray, Murray; Chong, Siow; Cohen, David; Crespo-Facorro, Benedicto; Crowley, James; Davidson, David; Delisi, Lynn; Dinan, Timothy; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Haan, Lieuwe; Hougaard, David; Karachanak-Yankova, Sena; Khrunin, Andrey; Klovins, Janis; Kučinskas, Vaidutis; Lee Chee Keong, Jim; Limborska, Svetlana; Loughland, Carmel; Lönnqvist, Jouko; Maher, Brion; Mattheisen, Manuel; Mcdonald, Colm; Murphy, Kieran; Murray, Robin; Nenadic, Igor; van Os, Jim; Pantelis, Chris; Pato, Michele, T.; Petryshen, Tracey; Quested, Digby, J.; Roussos, Panos; Sanders, Alan; Schall, Ulrich; Schwab, Sibylle; Sim, Kang; So, Hon-Cheong; Stögmann, Elisabeth; Subramaniam, Mythily; Toncheva, Draga; Waddington, John; Walters, James; Weiser, Mark; Cheng, Wei; Cloninger, Robert, C.; Curtis, David; Gejman, Pablo, V.; Henskens, Frans; Mattingsdal, Morten; Oh, Sang-Yun; Scott, Rodney; Webb, Bradley; Breen, Gerome; Churchhouse, Claire; Bulik, Cynthia; Daly, Mark, J.; Dichgans, Martin; Faraone, Stephen, V.; Guerreiro, Rita; Holmans, Peter; Kendler, Kenneth; Koeleman, Bobby; Mathews, Carol; Price, Alkes; Scharf, Jeremiah; Sklar, Pamela; Williams, Julie |
| Contributors: |
Massachusetts General Hospital Boston; Broad Institute of MIT and Harvard (BROAD INSTITUTE); Harvard Medical School Boston (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital Boston; UK Dementia Research Institute (UK DRI); University College London UCL (UCL); School of Psychology Cardiff University; Cardiff University; Institute for Stroke and Dementia Research (ISD); Klinikum der Universität München -Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU); New Jersey Institute of Technology Newark (NJIT); Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); RIKEN Center for Integrative Medical Sciences Yokohama (RIKEN IMS); RIKEN - Institute of Physical and Chemical Research Japon (RIKEN); Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC); Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM); Laboratoire de Biotechnologie et Microbiologie Appliquée (LBMA); Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA); Bordeaux population health (BPH); Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service de neurologie Rouen; CHU Rouen; Normandie Université (NU)-Normandie Université (NU); Institut de Biologie François JACOB (JACOB); Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA); Gériatrie générale et aigüe Paris; AP-HP - Hôpital Cochin Broca Hôtel Dieu Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Columbia University New York; Dpt of Neuroscience New York; Icahn School of Medicine at Mount Sinai New York (MSSM); University of Pittsburgh (PITT); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Washington Seattle; Tanz Center Research in Neurodegenerative Diseases Toronto; University of Toronto; Children’s Hospital of Philadelphia (CHOP); University of Kentucky (UK); School of medicine; Duke University Durham; College of medicine; Brigham Young University (BYU); Oregon Health and Science University Portland (OHSU); Cleveland Clinic; Department of Neurology; Emory University Atlanta, GA; Medical School; Université du Michigan = University of Michigan Ann Arbor (UMich); Health sciences center; The University of New Mexico Albuquerque; New Mexico Consortium (NMC)-New Mexico Consortium (NMC); Institute for Memory Impairments and Neurological Disorders Irvine; University of California Irvine (UC Irvine); University of California (UC)-University of California (UC); Indiana University - Purdue University Indianapolis (IUPUI); Indiana University System; Keck School of Medicine Los Angeles; University of Southern California (USC); University of South Florida Tampa (USF); School of Medicine University of Utah, Salt Lake City; University of Utah; Boston University School of Medicine (BUSM); Boston University Boston (BU); Perelman School of Medicine; University of Pennsylvania Philadelphia; Dublin City University Dublin (DCU); Functional Genomics Center Zurich; Universität Zürich Zürich = University of Zurich (UZH)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology Zürich (ETH Zürich); Cambridge Institute for Medical Research (CIMR); University of Cambridge Cambridge, UK (CAM); Aristotle University of Thessaloniki; Maurice Wohl Clinical Neuroscience Institut; King‘s College London; Dementia Research Centre London (DRC); Groupe de recherche clinique Alzheimer Precision Medicine (GRC 21 - APM); Sorbonne Université (SU); MRC Centre for Neuropsychiatric Genetics and Genomics; Medical Research Council-Cardiff University; MRC Prion Unit London; Queen's University Belfast (QUB); School of Life Sciences; University of Nottingham, UK (UON); Rheinische Friedrich-Wilhelms-Universität Bonn; Centre de Recherche en Cancérologie de Marseille (CRCM); Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC); Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); QIMR Berghofer Medical Research Institute; Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg (FAU); School of Medicine Dublin; Trinity College Dublin; Department of Medicine |
| Source: |
ISSN: 0036-8075. |
| Publisher Information: |
CCSD; American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2018 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
MESH: Brain Diseases; MESH: Genetic Variation; MESH: Genome-Wide Association Study; MESH: Humans; MESH: Mental Disorders; MESH: Phenotype; MESH: Quantitative Trait; Heritable; MESH: Risk Factors; [SDV]Life Sciences [q-bio]; [SDV.GEN]Life Sciences [q-bio]/Genetics; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| Description: |
International audience ; Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29930110; PUBMED: 29930110; PUBMEDCENTRAL: PMC6097237 |
| DOI: |
10.1126/science.aap8757 |
| Availability: |
https://cea.hal.science/cea-01870483; https://cea.hal.science/cea-01870483v1/document; https://cea.hal.science/cea-01870483v1/file/Antils.pdf; https://doi.org/10.1126/science.aap8757 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.D0641B8E |
| Database: |
BASE |