| Title: |
Effect of leukocyte telomere length on total and regional brain volumes in a large population-based cohort |
| Authors: |
King, Kevin S; Kozlitina, Julia; Rosenberg, Roger N; Peshock, Ronald M; McColl, Roderick W; Garcia, Christine K |
| Source: |
Neuroradiology |
| Publisher Information: |
Barrow - St. Joseph's Scholarly Commons |
| Publication Year: |
2014 |
| Subject Terms: |
Adolescent; Adult; Aged; 80 and over; Aging (genetics; pathology); Amygdala (pathology); Brain (pathology); Cerebral Cortex (pathology); Cohort Studies; Diencephalon (pathology); Female; Frontal Lobe (pathology); Gray Matter (pathology); Gyrus Cinguli (pathology); Hippocampus (pathology); Humans; Image Processing; Computer-Assisted; Leukocytes (ultrastructure); Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Parietal Lobe (pathology); Telomere (genetics); Temporal Lobe (pathology); Thalamus (pathology); White Matter (pathology); Young Adult |
| Description: |
IMPORTANCE: Telomere length has been associated with dementia and psychological stress, but its relationship with human brain size is unknown. OBJECTIVE: To determine if peripheral blood telomere length is associated with brain volume. DESIGN, SETTING, AND PARTICIPANTS: Peripheral blood leukocyte telomere length and brain volumes were measured for 1960 individuals in the Dallas Heart Study, a population-based, probability sample of Dallas County, Texas, residents, with a median (25th-75th percentile) age of 50 (42-58) years. Global and 48 regional brain volumes were assessed from the automated analysis of magnetic resonance imaging. MAIN OUTCOMES AND MEASURES: Telomere length and global and regional brain volumes. RESULTS: Leukocyte telomere length was associated with total cerebral volume (β [SE], 0.06 [0.01], P |
| Document Type: |
text |
| Language: |
unknown |
| Relation: |
https://scholar.barrowneuro.org/neuroradiology/47; https://doi.org/10.1001/jamaneurol.2014.1926 |
| DOI: |
10.1001/jamaneurol.2014.1926 |
| Availability: |
https://scholar.barrowneuro.org/neuroradiology/47; https://doi.org/10.1001/jamaneurol.2014.1926 |
| Accession Number: |
edsbas.D0734FD2 |
| Database: |
BASE |